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Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts

Genomic locus at chromosome 9p21 that contains the CDKN2A and CDKN2B tumor suppressor genes is inactivated through mutations, deletions and promoter methylation in multiple human cancers. Additionally, the locus encodes an anti-sense RNA (ANRIL). Both hemizygous and homozygous deletions at the locus...

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Detalles Bibliográficos
Autores principales:	Xie, Huaping, Rachakonda, P. Sivaramakrishna, Heidenreich, Barbara, Nagore, Eduardo, Sucker, Antje, Hemminki, Kari, Schadendorf, Dirk, Kumar, Rajiv
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941330/ https://www.ncbi.nlm.nih.gov/pubmed/26909863 http://dx.doi.org/10.18632/oncotarget.7503

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