Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation

The thioredoxin reductase (TrxR) 1 is often overexpressed in numerous cancer cells. Targeting TrxR1 leads to a reduction in tumor progression and metastasis, making the enzyme an attractive target for cancer treatment. Our previous research revealed that the curcumin derivative B19 could induce canc...

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Detalles Bibliográficos
Autores principales: Chen, Weiqian, Zou, Peng, Zhao, Zhongwei, Weng, Qiaoyou, Chen, Xi, Ying, Shilong, Ye, Qingqing, Wang, Zhe, Ji, Jiansong, Liang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941337/
https://www.ncbi.nlm.nih.gov/pubmed/26919094
http://dx.doi.org/10.18632/oncotarget.7565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941337/
https://www.ncbi.nlm.nih.gov/pubmed/26919094
http://dx.doi.org/10.18632/oncotarget.7565

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