Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

The membrane-associated matrix metalloproteinase-14, MT1-MMP, has been implicated in pericellular proteolysis with an important role in cellular invasion of collagenous tissues. It is substantially upregulated in various cancers and rheumatoid arthritis, and has been considered as a potential therap...

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Detalles Bibliográficos
Autores principales: Botkjaer, Kenneth A., Kwok, Hang Fai, Terp, Mikkel G., Karatt-Vellatt, Aneesh, Santamaria, Salvatore, McCafferty, John, Andreasen, Peter A., Itoh, Yoshifumi, Ditzel, Henrik J., Murphy, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941350/
https://www.ncbi.nlm.nih.gov/pubmed/26934448
http://dx.doi.org/10.18632/oncotarget.7780

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