Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites

N-of-1 trials target actionable mutations, yet such approaches do not test genomically-informed therapies in patient tumor models prior to patient treatment. To address this, we developed patient-derived xenograft (PDX) models from fine needle aspiration (FNA) biopsies (FNA-PDX) obtained from primar...

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Detalles Bibliográficos
Autores principales: Allaway, Robert J., Fischer, Dawn A., de Abreu, Francine B., Gardner, Timothy B., Gordon, Stuart R., Barth, Richard J., Colacchio, Thomas A., Wood, Matthew, Kacsoh, Balint Z., Bouley, Stephanie J., Cui, Jingxuan, Hamilton, Joanna, Choi, Jungbin A., Lange, Joshua T., Peterson, Jason D., Padmanabhan, Vijayalakshmi, Tomlinson, Craig R., Tsongalis, Gregory J., Suriawinata, Arief A., Greene, Casey S., Sanchez, Yolanda, Smith, Kerrington D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941373/
https://www.ncbi.nlm.nih.gov/pubmed/26934555
http://dx.doi.org/10.18632/oncotarget.7718

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