Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma

Tumor cells co-express vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) that interact each other to support a self-sustainable cell growth. So far, this autocrine VEGF loop is not reported in human intrahepatic cholangiocarcinoma (ICC). Apatinib is a highly selective VEGFR2 inhi...

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Detalles Bibliográficos
Autores principales: Peng, Hong, Zhang, Qiuyang, Li, Jiali, Zhang, Ning, Hua, Yunpeng, Xu, Lixia, Deng, Yubin, Lai, Jiaming, Peng, Zhenwei, Peng, Baogang, Chen, Minhu, Peng, Sui, Kuang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941382/
https://www.ncbi.nlm.nih.gov/pubmed/26967384
http://dx.doi.org/10.18632/oncotarget.7948

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