Cargando…

A Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors

The human histone deacetylase isoform 6 (HDAC6) has been demonstrated to play a major role in cell motility and aggresome formation, being interesting for the treatment of multiple tumour types and neurodegenerative conditions. Currently, most HDAC inhibitors in preclinical or clinical evaluations a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goracci, Laura, Deschamps, Nathalie, Randazzo, Giuseppe Marco, Petit, Charlotte, Dos Santos Passos, Carolina, Carrupt, Pierre-Alain, Simões-Pires, Claudia, Nurisso, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941420/ https://www.ncbi.nlm.nih.gov/pubmed/27404291 http://dx.doi.org/10.1038/srep29086

Ejemplares similares

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
por: Simões-Pires, Claudia, et al.
Publicado: (2013)

Computational Studies on Sirtuins from Trypanosoma cruzi: Structures, Conformations and Interactions with Phytochemicals
por: Sacconnay, Lionel, et al.
Publicado: (2014)

Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6
por: Traoré, Mohamed D. M., et al.
Publicado: (2017)

Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids
por: Jakubkiene, Virginija, et al.
Publicado: (2022)

Hydroxamic acid derivatives as HDAC1, HDAC6 and HDAC8 inhibitors with antiproliferative activity in cancer cell lines
por: Sixto-López, Yudibeth, et al.
Publicado: (2020)

Molecular docking and ADMET analysis of hydroxamic acids as HDAC2 inhibitors
por: Alsawalha, Murad, et al.
Publicado: (2019)

Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual‐Targeting HDAC Inhibitors and HDAC Degraders (PROTACs)
por: Sinatra, Laura, et al.
Publicado: (2020)

A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth
por: Kaliszczak, M, et al.
Publicado: (2013)

Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies
por: García, Santiago, et al.
Publicado: (2020)

Study of Leaf Metabolome Modifications Induced by UV-C Radiations in Representative Vitis, Cissus and Cannabis Species by LC-MS Based Metabolomics and Antioxidant Assays
por: Marti, Guillaume, et al.
Publicado: (2014)

In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC)
por: Tambunan, Usman SF, et al.
Publicado: (2011)

LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington’s Disease
por: Chopra, Vanita, et al.
Publicado: (2016)

PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells
por: Rivera-Del Valle, Nilsa, et al.
Publicado: (2010)

Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Bearing a Pyrazole Scaffold and a Cinnamoyl Linker
por: Zagni, Chiara, et al.
Publicado: (2019)

Hydroxamic Acid-Modified Peptide Library Provides Insights into the Molecular Basis for the Substrate Selectivity of HDAC Corepressor Complexes
por: Archibald, Lewis J., et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities
por: Yang, Feifei, et al.
Publicado: (2019)

Molecular and cellular effects of a novel hydroxamate-based HDAC inhibitor – belinostat – in glioblastoma cell lines: a preliminary report
por: Kusaczuk, Magdalena, et al.
Publicado: (2016)

Permanent Porosity in Hydroxamate Titanium–Organic Polyhedra
por: Lerma-Berlanga, Belén, et al.
Publicado: (2021)

Interaction of Imidazole Containing Hydroxamic Acids with Fe(III): Hydroxamate Versus Imidazole Coordination of the Ligands
por: Farkas, Etelka, et al.
Publicado: (2007)

Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure–Activity Relations of New Inhibitors of HDAC and/or Tubulin Function
por: Schmitt, Florian, et al.
Publicado: (2019)

Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine–hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer
por: Abdel-Atty, Mona M., et al.
Publicado: (2021)

Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis
por: Luo, Kui, et al.
Publicado: (2022)

Stereoselective Inhibition of the hERG1 Potassium Channel
por: Grilo, Liliana Sintra, et al.
Publicado: (2010)

Selectivity of Benzyl Hydroxamic Acid in the Flotation of Ilmenite
por: Li, Lixia, et al.
Publicado: (2019)

The Race for Hydroxamate-Based Zirconium-89 Chelators
por: Feiner, Irene V. J., et al.
Publicado: (2021)

Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors
por: Leipoldt, Franziska, et al.
Publicado: (2017)

Molecular dynamics simulation of complex Histones Deacetylase (HDAC) Class II Homo Sapiens with suberoylanilide hydroxamic acid (SAHA) and its derivatives as inhibitors of cervical cancer
por: Tambunan, Usman Sumo Friend, et al.
Publicado: (2013)

Correction: Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis
por: Luo, Kui, et al.
Publicado: (2022)

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
por: Linnert, Miriam, et al.
Publicado: (2021)

Histone Deacetylase (HDAC) Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), Induces Apoptosis in Prostate Cancer Cell Lines via the Akt/FOXO3a Signaling Pathway
por: Shi, Xuan-Yan, et al.
Publicado: (2017)

Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma
por: Kassab, Shaymaa E., et al.
Publicado: (2019)

Hydrogen bonding abilities of hydroxamic acid and its isosteres
por: Kohli, Ruchi
Publicado: (2016)

Hydroxamic acid – A novel molecule for anticancer therapy
por: Pal, Dilipkumar, et al.
Publicado: (2012)

Antiradical, Chelating and Antioxidant Activities of Hydroxamic Acids and Hydroxyureas
por: Končić, Marijana Zovko, et al.
Publicado: (2011)

Cross metathesis-mediated synthesis of hydroxamic acid derivatives
por: Chattopadhyay, Shital Kumar, et al.
Publicado: (2018)

A general concept for the introduction of hydroxamic acids into polymers
por: Johann, Tobias, et al.
Publicado: (2019)

Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth
por: Said, Thenaa K, et al.
Publicado: (2001)

Zinc cross-linked hydroxamated alginates for pulsed drug release
por: Raut, Neha S, et al.
Publicado: (2013)

Suberoylanilide hydroxamic acid represses glioma stem-like cells
por: Hsu, Che-Chia, et al.
Publicado: (2016)

ING5‐mediated antineuroblastoma effects of suberoylanilide hydroxamic acid
por: Wu, Ji‐cheng, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ih831eee8epjt077tqlebt594d