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A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant
Insertions in the Salmonella enterica fra locus, which encodes the fructose-asparagine (F-Asn) utilization pathway, are highly attenuated in mouse models of inflammation (>1000-fold competitive index). Here, we report that F-Asn is bacteriostatic to a fraB mutant (IC(50) 19 μM), but not to the wi...
Autores principales: | Sabag-Daigle, Anice, Blunk, Henry M., Sengupta, Anindita, Wu, Jikang, Bogard, Alexander J., Ali, Mohamed M., Stahl, Christopher, Wysocki, Vicki H., Gopalan, Venkat, Behrman, Edward J., Ahmer, Brian M. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941530/ https://www.ncbi.nlm.nih.gov/pubmed/27403719 http://dx.doi.org/10.1038/srep28117 |
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