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The pathogenesis of multifocal osteonecrosis
Our objective was to study the incidence, etiology, and diagnosis of multifocal osteonecrosis (MFON) and its treatment options to facilitate an earlier diagnosis and to optimize treatment. A radiological investigation was performed in osteonecrosis patients with a high risk of MFON for a more accura...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941719/ https://www.ncbi.nlm.nih.gov/pubmed/27404962 http://dx.doi.org/10.1038/srep29576 |
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author | Sun, Wei Shi, Zhencai Gao, Fuqiang Wang, Bailiang Li, Zirong |
author_facet | Sun, Wei Shi, Zhencai Gao, Fuqiang Wang, Bailiang Li, Zirong |
author_sort | Sun, Wei |
collection | PubMed |
description | Our objective was to study the incidence, etiology, and diagnosis of multifocal osteonecrosis (MFON) and its treatment options to facilitate an earlier diagnosis and to optimize treatment. A radiological investigation was performed in osteonecrosis patients with a high risk of MFON for a more accurate diagnosis between January 2010 and June 2015. For patients with osteonecrosis of both the hip and knee joints or for patients with a history of corticosteroid use or alcohol abuse who had osteonecrosis of one or more joints in the shoulder, ankle, wrist or elbow, magnetic resonance imaging (MRI) was also performed on other joints, regardless of whether these joints were symptomatic. Furthermore, we performed a radiological screening of 102 patients who had a negative diagnosis of MFON but were at a high risk; among them, another 31 MFON cases were successfully identified (30.4%). Thus, the incidence of MFON during the study period increased from 3.1% to 5.2%. Patients diagnosed with osteonecrosis and who are at a high risk of MFON should have their other joints radiologically examined when necessary. This will reduce missed diagnosis of MFON and facilitate an earlier diagnosis and treatment to achieve an optimal outcome. |
format | Online Article Text |
id | pubmed-4941719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49417192016-07-20 The pathogenesis of multifocal osteonecrosis Sun, Wei Shi, Zhencai Gao, Fuqiang Wang, Bailiang Li, Zirong Sci Rep Article Our objective was to study the incidence, etiology, and diagnosis of multifocal osteonecrosis (MFON) and its treatment options to facilitate an earlier diagnosis and to optimize treatment. A radiological investigation was performed in osteonecrosis patients with a high risk of MFON for a more accurate diagnosis between January 2010 and June 2015. For patients with osteonecrosis of both the hip and knee joints or for patients with a history of corticosteroid use or alcohol abuse who had osteonecrosis of one or more joints in the shoulder, ankle, wrist or elbow, magnetic resonance imaging (MRI) was also performed on other joints, regardless of whether these joints were symptomatic. Furthermore, we performed a radiological screening of 102 patients who had a negative diagnosis of MFON but were at a high risk; among them, another 31 MFON cases were successfully identified (30.4%). Thus, the incidence of MFON during the study period increased from 3.1% to 5.2%. Patients diagnosed with osteonecrosis and who are at a high risk of MFON should have their other joints radiologically examined when necessary. This will reduce missed diagnosis of MFON and facilitate an earlier diagnosis and treatment to achieve an optimal outcome. Nature Publishing Group 2016-07-11 /pmc/articles/PMC4941719/ /pubmed/27404962 http://dx.doi.org/10.1038/srep29576 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Sun, Wei Shi, Zhencai Gao, Fuqiang Wang, Bailiang Li, Zirong The pathogenesis of multifocal osteonecrosis |
title | The pathogenesis of multifocal osteonecrosis |
title_full | The pathogenesis of multifocal osteonecrosis |
title_fullStr | The pathogenesis of multifocal osteonecrosis |
title_full_unstemmed | The pathogenesis of multifocal osteonecrosis |
title_short | The pathogenesis of multifocal osteonecrosis |
title_sort | pathogenesis of multifocal osteonecrosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941719/ https://www.ncbi.nlm.nih.gov/pubmed/27404962 http://dx.doi.org/10.1038/srep29576 |
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