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Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages
It is well known that tumour-associated macrophages (TAMs) play an important role in tumour development by modulating the tumour microenvironment, and targeting of protumour activation or the M2 polarization of TAMs is expected to be an effective therapy for cancer patients. We previously demonstrat...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941721/ https://www.ncbi.nlm.nih.gov/pubmed/27404320 http://dx.doi.org/10.1038/srep29588 |
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author | Tsuboki, Junko Fujiwara, Yukio Horlad, Hasita Shiraishi, Daisuke Nohara, Toshihiro Tayama, Shingo Motohara, Takeshi Saito, Yoichi Ikeda, Tsuyoshi Takaishi, Kiyomi Tashiro, Hironori Yonemoto, Yukihiro Katabuchi, Hidetaka Takeya, Motohiro Komohara, Yoshihiro |
author_facet | Tsuboki, Junko Fujiwara, Yukio Horlad, Hasita Shiraishi, Daisuke Nohara, Toshihiro Tayama, Shingo Motohara, Takeshi Saito, Yoichi Ikeda, Tsuyoshi Takaishi, Kiyomi Tashiro, Hironori Yonemoto, Yukihiro Katabuchi, Hidetaka Takeya, Motohiro Komohara, Yoshihiro |
author_sort | Tsuboki, Junko |
collection | PubMed |
description | It is well known that tumour-associated macrophages (TAMs) play an important role in tumour development by modulating the tumour microenvironment, and targeting of protumour activation or the M2 polarization of TAMs is expected to be an effective therapy for cancer patients. We previously demonstrated that onionin A (ONA), a natural low molecular weight compound isolated from onions, has an inhibitory effect on M2 macrophage polarization. In the present study, we investigated whether ONA had a therapeutic anti-ovarian cancer effect using in vitro and in vivo studies. We found that ONA reduced the extent of ovarian cancer cell proliferation induced by co-culture with human macrophages. In addition, we also found that ONA directly suppressed cancer cell proliferation. A combinatorial effect with ONA and anti-cancer drugs was also observed. The activation of signal transducer and activator of transcription 3 (STAT3), which is involved in cell proliferation and chemo-resistance, was significantly abrogated by ONA in ovarian cancer cells. Furthermore, the administration of ONA suppressed cancer progression and prolonged the survival time in a murine ovarian cancer model under single and combined treatment conditions. Thus, ONA is considered useful for the additional treatment of patients with ovarian cancer owing to its suppression of the protumour activation of TAMs and direct cytotoxicity against cancer cells. |
format | Online Article Text |
id | pubmed-4941721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49417212016-07-20 Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages Tsuboki, Junko Fujiwara, Yukio Horlad, Hasita Shiraishi, Daisuke Nohara, Toshihiro Tayama, Shingo Motohara, Takeshi Saito, Yoichi Ikeda, Tsuyoshi Takaishi, Kiyomi Tashiro, Hironori Yonemoto, Yukihiro Katabuchi, Hidetaka Takeya, Motohiro Komohara, Yoshihiro Sci Rep Article It is well known that tumour-associated macrophages (TAMs) play an important role in tumour development by modulating the tumour microenvironment, and targeting of protumour activation or the M2 polarization of TAMs is expected to be an effective therapy for cancer patients. We previously demonstrated that onionin A (ONA), a natural low molecular weight compound isolated from onions, has an inhibitory effect on M2 macrophage polarization. In the present study, we investigated whether ONA had a therapeutic anti-ovarian cancer effect using in vitro and in vivo studies. We found that ONA reduced the extent of ovarian cancer cell proliferation induced by co-culture with human macrophages. In addition, we also found that ONA directly suppressed cancer cell proliferation. A combinatorial effect with ONA and anti-cancer drugs was also observed. The activation of signal transducer and activator of transcription 3 (STAT3), which is involved in cell proliferation and chemo-resistance, was significantly abrogated by ONA in ovarian cancer cells. Furthermore, the administration of ONA suppressed cancer progression and prolonged the survival time in a murine ovarian cancer model under single and combined treatment conditions. Thus, ONA is considered useful for the additional treatment of patients with ovarian cancer owing to its suppression of the protumour activation of TAMs and direct cytotoxicity against cancer cells. Nature Publishing Group 2016-07-12 /pmc/articles/PMC4941721/ /pubmed/27404320 http://dx.doi.org/10.1038/srep29588 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Tsuboki, Junko Fujiwara, Yukio Horlad, Hasita Shiraishi, Daisuke Nohara, Toshihiro Tayama, Shingo Motohara, Takeshi Saito, Yoichi Ikeda, Tsuyoshi Takaishi, Kiyomi Tashiro, Hironori Yonemoto, Yukihiro Katabuchi, Hidetaka Takeya, Motohiro Komohara, Yoshihiro Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages |
title | Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages |
title_full | Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages |
title_fullStr | Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages |
title_full_unstemmed | Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages |
title_short | Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages |
title_sort | onionin a inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941721/ https://www.ncbi.nlm.nih.gov/pubmed/27404320 http://dx.doi.org/10.1038/srep29588 |
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