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Association between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics

Few studies have assessed the association between the rs1414334 C/G polymorphism in the HTR2C gene and the development of the metabolic syndrome in patients treated with atypical antipsychotics. To provide further evidence, a cross-sectional study was conducted in Spain between 2012 and 2013 in 166...

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Detalles Bibliográficos
Autores principales: Rico-Gomis, José María, Palazón-Bru, Antonio, Triano-García, Irene, Mahecha-García, Luis Fabián, García-Monsalve, Ana, Navarro-Ruiz, Andrés, Villagordo-Peñalver, Berta, Jiménez-Abril, Jessica, Martínez-Hortelano, Alicia, Gil-Guillén, Vicente Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941738/
https://www.ncbi.nlm.nih.gov/pubmed/27441116
http://dx.doi.org/10.7717/peerj.2163
Descripción
Sumario:Few studies have assessed the association between the rs1414334 C/G polymorphism in the HTR2C gene and the development of the metabolic syndrome in patients treated with atypical antipsychotics. To provide further evidence, a cross-sectional study was conducted in Spain between 2012 and 2013 in 166 patients with these characteristics. In these patients, the association between the polymorphism and the presence of the metabolic syndrome was determined by implementing binary logistic regression models adjusted for variables associated with the metabolic syndrome. We did not confirm previous claims that the C allele of the polymorphism was linked to the metabolic syndrome: the association was in the opposite direction and non-significant. This conclusion held after taking gender and lifestyle variables into account.