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Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. Linn leaf extracts

The hepatoprotective potential of standardized Feronia limonia (Family, Rutaceae) methanolic extract (FL-7) and chloroform soluble fraction (FL-9) were assessed against carbon tetrachloride (CCl(4)) induced oxidative stress and hepatotoxicity in rats. Rats treated with CCl(4 )recorded significant el...

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Autores principales: Jain, Mahendra, Kapadia, Rakhee, Jadeja, Ravirajsinh N., Thounaojam, Menaka C., Devkar, Ranjitsinh V., Mishra, S.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941808/
https://www.ncbi.nlm.nih.gov/pubmed/27418903
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author Jain, Mahendra
Kapadia, Rakhee
Jadeja, Ravirajsinh N.
Thounaojam, Menaka C.
Devkar, Ranjitsinh V.
Mishra, S.H.
author_facet Jain, Mahendra
Kapadia, Rakhee
Jadeja, Ravirajsinh N.
Thounaojam, Menaka C.
Devkar, Ranjitsinh V.
Mishra, S.H.
author_sort Jain, Mahendra
collection PubMed
description The hepatoprotective potential of standardized Feronia limonia (Family, Rutaceae) methanolic extract (FL-7) and chloroform soluble fraction (FL-9) were assessed against carbon tetrachloride (CCl(4)) induced oxidative stress and hepatotoxicity in rats. Rats treated with CCl(4 )recorded significant elevation in plasma markers of hepatic injury, alteration in hepatic antioxidant status and histopathological damages. However, rats pretreated with FL-7 (200 or 400 mg/kg, p.o.) and FL-9 (100 or 200 mg/kg, p.o.) for 7 days and later administered CCl(4) (0.5 ml/kg, i.p.) recorded lowered indices of the above mentioned parameters and minimal histological damage in a dose dependent manner. These results were comparable to that of CCl(4)+silymarin treated rats. The results obtained with FL-7 and FL-9 are attributable to their free radical scavenging potential due to high contents of polyphenols and flavonols recorded herein. Overall, this study establishes the efficacy of FL-7 and FL-9 as hepatoprotective agents against CCl(4 )induced hepatotoxicity in rats.
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spelling pubmed-49418082016-07-14 Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. Linn leaf extracts Jain, Mahendra Kapadia, Rakhee Jadeja, Ravirajsinh N. Thounaojam, Menaka C. Devkar, Ranjitsinh V. Mishra, S.H. EXCLI J Original Article The hepatoprotective potential of standardized Feronia limonia (Family, Rutaceae) methanolic extract (FL-7) and chloroform soluble fraction (FL-9) were assessed against carbon tetrachloride (CCl(4)) induced oxidative stress and hepatotoxicity in rats. Rats treated with CCl(4 )recorded significant elevation in plasma markers of hepatic injury, alteration in hepatic antioxidant status and histopathological damages. However, rats pretreated with FL-7 (200 or 400 mg/kg, p.o.) and FL-9 (100 or 200 mg/kg, p.o.) for 7 days and later administered CCl(4) (0.5 ml/kg, i.p.) recorded lowered indices of the above mentioned parameters and minimal histological damage in a dose dependent manner. These results were comparable to that of CCl(4)+silymarin treated rats. The results obtained with FL-7 and FL-9 are attributable to their free radical scavenging potential due to high contents of polyphenols and flavonols recorded herein. Overall, this study establishes the efficacy of FL-7 and FL-9 as hepatoprotective agents against CCl(4 )induced hepatotoxicity in rats. Leibniz Research Centre for Working Environment and Human Factors 2012-05-23 /pmc/articles/PMC4941808/ /pubmed/27418903 Text en Copyright © 2012 Jain et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Jain, Mahendra
Kapadia, Rakhee
Jadeja, Ravirajsinh N.
Thounaojam, Menaka C.
Devkar, Ranjitsinh V.
Mishra, S.H.
Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. Linn leaf extracts
title Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. Linn leaf extracts
title_full Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. Linn leaf extracts
title_fullStr Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. Linn leaf extracts
title_full_unstemmed Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. Linn leaf extracts
title_short Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. Linn leaf extracts
title_sort amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized feronia limonia. linn leaf extracts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941808/
https://www.ncbi.nlm.nih.gov/pubmed/27418903
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