In-vivo imaging of dendritic pruning in dentate granule cells

We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment (EE) and constraining dendritic growth by disrupting Wnt signaling led to increased branch addition...

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Detalles Bibliográficos
Autores principales: Gonçalves, J. Tiago, Bloyd, Cooper W., Shtrahman, Matthew, Johnston, Stephen T., Schafer, Simon T., Parylak, Sarah L., Tran, Thanh, Chang, Tina, Gage, Fred H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941946/
https://www.ncbi.nlm.nih.gov/pubmed/27135217
http://dx.doi.org/10.1038/nn.4301
Descripción
Sumario:We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment (EE) and constraining dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

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