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Time Varying Apparent Volume of Distribution and Drug Half-Lives Following Intravenous Bolus Injections
We present a model that generalizes the apparent volume of distribution and half-life as functions of time following intravenous bolus injection. This generalized model defines a time varying apparent volume of drug distribution. The half-lives of drug remaining in the body vary in time and become l...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942076/ https://www.ncbi.nlm.nih.gov/pubmed/27403663 http://dx.doi.org/10.1371/journal.pone.0158798 |