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Place cells on a maze encode routes rather than destinations
Hippocampal place cells fire at different rates when a rodent runs through a given location on its way to different destinations. However, it is unclear whether such firing represents the animal’s intended destination or the execution of a specific trajectory. To distinguish between these possibilit...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942257/ https://www.ncbi.nlm.nih.gov/pubmed/27282386 http://dx.doi.org/10.7554/eLife.15986 |
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author | Grieves, Roddy M Wood, Emma R Dudchenko, Paul A |
author_facet | Grieves, Roddy M Wood, Emma R Dudchenko, Paul A |
author_sort | Grieves, Roddy M |
collection | PubMed |
description | Hippocampal place cells fire at different rates when a rodent runs through a given location on its way to different destinations. However, it is unclear whether such firing represents the animal’s intended destination or the execution of a specific trajectory. To distinguish between these possibilities, Lister Hooded rats (n = 8) were trained to navigate from a start box to three goal locations via four partially overlapping routes. Two of these led to the same goal location. Of the cells that fired on these two routes, 95.8% showed route-dependent firing (firing on only one route), whereas only two cells (4.2%) showed goal-dependent firing (firing similarly on both routes). In addition, route-dependent place cells over-represented the less discriminable routes, and place cells in general over-represented the start location. These results indicate that place cell firing on overlapping routes reflects the animal’s route, not its goals, and that this firing may aid spatial discrimination. DOI: http://dx.doi.org/10.7554/eLife.15986.001 |
format | Online Article Text |
id | pubmed-4942257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49422572016-07-14 Place cells on a maze encode routes rather than destinations Grieves, Roddy M Wood, Emma R Dudchenko, Paul A eLife Neuroscience Hippocampal place cells fire at different rates when a rodent runs through a given location on its way to different destinations. However, it is unclear whether such firing represents the animal’s intended destination or the execution of a specific trajectory. To distinguish between these possibilities, Lister Hooded rats (n = 8) were trained to navigate from a start box to three goal locations via four partially overlapping routes. Two of these led to the same goal location. Of the cells that fired on these two routes, 95.8% showed route-dependent firing (firing on only one route), whereas only two cells (4.2%) showed goal-dependent firing (firing similarly on both routes). In addition, route-dependent place cells over-represented the less discriminable routes, and place cells in general over-represented the start location. These results indicate that place cell firing on overlapping routes reflects the animal’s route, not its goals, and that this firing may aid spatial discrimination. DOI: http://dx.doi.org/10.7554/eLife.15986.001 eLife Sciences Publications, Ltd 2016-06-10 /pmc/articles/PMC4942257/ /pubmed/27282386 http://dx.doi.org/10.7554/eLife.15986 Text en © 2016, Grieves et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Grieves, Roddy M Wood, Emma R Dudchenko, Paul A Place cells on a maze encode routes rather than destinations |
title | Place cells on a maze encode routes rather than destinations |
title_full | Place cells on a maze encode routes rather than destinations |
title_fullStr | Place cells on a maze encode routes rather than destinations |
title_full_unstemmed | Place cells on a maze encode routes rather than destinations |
title_short | Place cells on a maze encode routes rather than destinations |
title_sort | place cells on a maze encode routes rather than destinations |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942257/ https://www.ncbi.nlm.nih.gov/pubmed/27282386 http://dx.doi.org/10.7554/eLife.15986 |
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