Genes with monoallelic expression contribute disproportionately to genetic diversity in humans

An unexpectedly large number of human autosomal genes are subject to monoallelic expression (MAE). Our analysis of 4,227 such genes reveals surprisingly high genetic variation across human populations. This increased diversity is unlikely to reflect relaxed purifying selection. Remarkably, MAE genes...

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Detalles Bibliográficos
Autores principales: Savova, Virginia, Chun, Sung, Sohail, Mashaal, McCole, Ruth B., Witwicki, Robert, Gai, Lisa, Lenz, Tobias L., Wu, C.-ting, Sunyaev, Shamil R., Gimelbrant, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942303/
https://www.ncbi.nlm.nih.gov/pubmed/26808112
http://dx.doi.org/10.1038/ng.3493

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