Cargando…

Effects of colchicine on pericardial diseases: a review of the literature and current evidence

Colchicine, extracted from the colchicum autumnale plant, used by the ancient Greeks more than 20 centuries ago, is one of the most ancient drugs still prescribed even today. The major mechanism of action is binding to microtubules thereby interfering with mitosis and subsequent modulation of polymo...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Syed Raza, Alweis, Richard, Shah, Syed Arbab, Arshad, Mohammad Hussham, Manji, Adil Al-Karim, Arfeen, Arham Amir, Javed, Maheen, Shujauddin, Syed Muhammad, Irfan, Rida, Shabbir, Sakina, Shaikh, Shehryar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942520/
https://www.ncbi.nlm.nih.gov/pubmed/27406462
http://dx.doi.org/10.3402/jchimp.v6.31957
_version_ 1782442424193253376
author Shah, Syed Raza
Alweis, Richard
Shah, Syed Arbab
Arshad, Mohammad Hussham
Manji, Adil Al-Karim
Arfeen, Arham Amir
Javed, Maheen
Shujauddin, Syed Muhammad
Irfan, Rida
Shabbir, Sakina
Shaikh, Shehryar
author_facet Shah, Syed Raza
Alweis, Richard
Shah, Syed Arbab
Arshad, Mohammad Hussham
Manji, Adil Al-Karim
Arfeen, Arham Amir
Javed, Maheen
Shujauddin, Syed Muhammad
Irfan, Rida
Shabbir, Sakina
Shaikh, Shehryar
author_sort Shah, Syed Raza
collection PubMed
description Colchicine, extracted from the colchicum autumnale plant, used by the ancient Greeks more than 20 centuries ago, is one of the most ancient drugs still prescribed even today. The major mechanism of action is binding to microtubules thereby interfering with mitosis and subsequent modulation of polymorphonuclear leukocyte function. Colchicine has long been of interest in the treatment of cardiovascular disease; however, its efficacy and safety profile for specific conditions have been variably established in the literature. In the subset of pericardial diseases, colchicine has been shown to be effective in recurrent pericarditis and post-pericardiotomy syndrome (PPS). The future course of treatment and management will therefore highly depend on the results of the ongoing large randomized placebo-controlled clinical trial to evaluate the efficacy and safety of colchicine for the primary prevention of several postoperative complications and in the perioperative period. Also, given the positive preliminary outcomes of colchicine usage in pericardial effusions, the future therapeutical use of colchicine looks promising. Further study is needed to clarify its role in these disease states, as well as explore other its role in other cardiovascular conditions.
format Online
Article
Text
id pubmed-4942520
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Co-Action Publishing
record_format MEDLINE/PubMed
spelling pubmed-49425202016-08-01 Effects of colchicine on pericardial diseases: a review of the literature and current evidence Shah, Syed Raza Alweis, Richard Shah, Syed Arbab Arshad, Mohammad Hussham Manji, Adil Al-Karim Arfeen, Arham Amir Javed, Maheen Shujauddin, Syed Muhammad Irfan, Rida Shabbir, Sakina Shaikh, Shehryar J Community Hosp Intern Med Perspect Review Article Colchicine, extracted from the colchicum autumnale plant, used by the ancient Greeks more than 20 centuries ago, is one of the most ancient drugs still prescribed even today. The major mechanism of action is binding to microtubules thereby interfering with mitosis and subsequent modulation of polymorphonuclear leukocyte function. Colchicine has long been of interest in the treatment of cardiovascular disease; however, its efficacy and safety profile for specific conditions have been variably established in the literature. In the subset of pericardial diseases, colchicine has been shown to be effective in recurrent pericarditis and post-pericardiotomy syndrome (PPS). The future course of treatment and management will therefore highly depend on the results of the ongoing large randomized placebo-controlled clinical trial to evaluate the efficacy and safety of colchicine for the primary prevention of several postoperative complications and in the perioperative period. Also, given the positive preliminary outcomes of colchicine usage in pericardial effusions, the future therapeutical use of colchicine looks promising. Further study is needed to clarify its role in these disease states, as well as explore other its role in other cardiovascular conditions. Co-Action Publishing 2016-07-06 /pmc/articles/PMC4942520/ /pubmed/27406462 http://dx.doi.org/10.3402/jchimp.v6.31957 Text en © 2016 Syed Raza Shah et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shah, Syed Raza
Alweis, Richard
Shah, Syed Arbab
Arshad, Mohammad Hussham
Manji, Adil Al-Karim
Arfeen, Arham Amir
Javed, Maheen
Shujauddin, Syed Muhammad
Irfan, Rida
Shabbir, Sakina
Shaikh, Shehryar
Effects of colchicine on pericardial diseases: a review of the literature and current evidence
title Effects of colchicine on pericardial diseases: a review of the literature and current evidence
title_full Effects of colchicine on pericardial diseases: a review of the literature and current evidence
title_fullStr Effects of colchicine on pericardial diseases: a review of the literature and current evidence
title_full_unstemmed Effects of colchicine on pericardial diseases: a review of the literature and current evidence
title_short Effects of colchicine on pericardial diseases: a review of the literature and current evidence
title_sort effects of colchicine on pericardial diseases: a review of the literature and current evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942520/
https://www.ncbi.nlm.nih.gov/pubmed/27406462
http://dx.doi.org/10.3402/jchimp.v6.31957
work_keys_str_mv AT shahsyedraza effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT alweisrichard effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT shahsyedarbab effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT arshadmohammadhussham effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT manjiadilalkarim effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT arfeenarhamamir effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT javedmaheen effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT shujauddinsyedmuhammad effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT irfanrida effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT shabbirsakina effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence
AT shaikhshehryar effectsofcolchicineonpericardialdiseasesareviewoftheliteratureandcurrentevidence