Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells

The precise identity of a tumour's cell of origin can influence disease prognosis and outcome. Methods to reliably define tumour cell of origin from primary, bulk tumour cell samples has been a challenge. Here we use a well-defined model of MLL-rearranged acute myeloid leukaemia (AML) to demons...

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Detalles Bibliográficos
Autores principales: George, Joshy, Uyar, Asli, Young, Kira, Kuffler, Lauren, Waldron-Francis, Kaiden, Marquez, Eladio, Ucar, Duygu, Trowbridge, Jennifer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942573/
https://www.ncbi.nlm.nih.gov/pubmed/27397025
http://dx.doi.org/10.1038/ncomms12166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942573/
https://www.ncbi.nlm.nih.gov/pubmed/27397025
http://dx.doi.org/10.1038/ncomms12166

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