Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

Compelling evidence has indicated that dysregulated glucose metabolism links Alzheimer’s disease (AD) and diabetes mellitus (DM) via glucose metabolic products. Nevertheless, because of the lack of appropriate animal models, whether chronic hyperglycemia worsens AD pathologies in vivo remains to be...

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Detalles Bibliográficos
Autores principales: Guo, Chuang, Zhang, Shuai, Li, Jia-Yi, Ding, Chen, Yang, Zhao-Hui, Chai, Rui, Wang, Xu, Wang, Zhan-You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942607/
https://www.ncbi.nlm.nih.gov/pubmed/27406855
http://dx.doi.org/10.1038/srep29396

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