DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo

Redox homeostasis is tightly controlled in cells as it is critical for most cellular functions. Iron-Sulfur centers (Fe-S) are metallic cofactors with electronic properties that are associated with proteins and allow fine redox tuning. Following the observation that altered Fe-S biosynthesis is corr...

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Detalles Bibliográficos
Autores principales: Huang, Meng-Er, Facca, Céline, Fatmi, Zakaria, Baïlle, Dorothée, Bénakli, Safia, Vernis, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942693/
https://www.ncbi.nlm.nih.gov/pubmed/27405729
http://dx.doi.org/10.1038/srep29361

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