Cargando…

Induced Pluripotent Stem Cells in Huntington’s Disease Research: Progress and Opportunity

Induced pluripotent stem cells (iPSCs) derived from controls and patients can act as a starting point for in vitro differentiation into human brain cells for discovery of novel targets and treatments for human disease without the same ethical limitations posed by embryonic stem cells. Numerous group...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tousley, Adelaide, Kegel-Gleason, Kimberly B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942721/ https://www.ncbi.nlm.nih.gov/pubmed/27372054 http://dx.doi.org/10.3233/JHD-160199

Ejemplares similares

Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells
por: Mueller, Kaly A., et al.
Publicado: (2018)

Taming the Huntington’s Disease Proteome: What Have We Learned?
por: Seeley, Connor, et al.
Publicado: (2021)

Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease
por: Tousley, Adelaide, et al.
Publicado: (2019)

Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes
por: Tousley, Adelaide, et al.
Publicado: (2019)

Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HD(Q175/Q7) Mice
por: Vodicka, Petr, et al.
Publicado: (2016)

Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells
por: Zhang, Ningzhe, et al.
Publicado: (2010)

Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons
por: Nekrasov, Evgeny D., et al.
Publicado: (2016)

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum
por: Iuliano, Maria, et al.
Publicado: (2021)

Transplantation of Induced Pluripotent Stem Cells Improves Functional Recovery in Huntington's Disease Rat Model
por: Mu, Shuhua, et al.
Publicado: (2014)

Emerging opportunities for induced pluripotent stem cells in orthopaedics
por: Li, Wan-Ju, et al.
Publicado: (2019)

Opportunities and Limitations of Modelling Alzheimer’s Disease with Induced Pluripotent Stem Cells
por: Ovchinnikov, Dmitry A., et al.
Publicado: (2014)

Genomic Instability Associated with p53 Knockdown in the Generation of Huntington’s Disease Human Induced Pluripotent Stem Cells
por: Tidball, Andrew M., et al.
Publicado: (2016)

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells
por: Juopperi, Tarja A, et al.
Publicado: (2012)

Reversal of Cellular Phenotypes in Neural Cells Derived from Huntington’s Disease Monkey-Induced Pluripotent Stem Cells
por: Carter, Richard L., et al.
Publicado: (2014)

Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease
por: Wu, Yi-Ying, et al.
Publicado: (2019)

Induced Pluripotent Stem Cells: Challenges and Opportunities for Cancer Immunotherapy
por: Sachamitr, Patty, et al.
Publicado: (2014)

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting
por: Lopes, Carla, et al.
Publicado: (2020)

The Progress of Induced Pluripotent Stem Cells as Models of Parkinson's Disease
por: Kang, Ji-feng, et al.
Publicado: (2016)

Induced pluripotent stem cells from Huntington’s disease patients: a promising approach to define and correct disease-related alterations
por: Fatima, Azra, et al.
Publicado: (2019)

Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges
por: Aalto-Setälä, Katriina, et al.
Publicado: (2009)

The difficulty to model Huntington’s disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells
por: Le Cann, Kim, et al.
Publicado: (2021)

Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease
por: Choompoo, Narawadee, et al.
Publicado: (2021)

The Opportunities and Challenges regarding Induced Platelets from Human Pluripotent Stem Cells
por: Xu, Meng-Xue, et al.
Publicado: (2021)

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
por: Koyuncu, Seda, et al.
Publicado: (2018)

Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington’s Disease Monkey pluripotent stem cells
por: Goodnight, Alexandra V., et al.
Publicado: (2019)

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells
por: Xu, Xiaohong, et al.
Publicado: (2017)

Neural Transplants From Human Induced Pluripotent Stem Cells Rescue the Pathology and Behavioral Defects in a Rodent Model of Huntington’s Disease
por: Yoon, Yongwoo, et al.
Publicado: (2020)

Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities
por: Kim, Tae Wan, et al.
Publicado: (2020)

Induced Pluripotent Stem Cells: Global Research Trends
por: Negoro, Takaharu, et al.
Publicado: (2017)

Pluripotency of induced pluripotent stem cells
por: Kang, Lan, et al.
Publicado: (2012)

Pluripotency of Induced Pluripotent Stem Cells
por: Feng, Chunjing, et al.
Publicado: (2013)

Pluripotent stem cells for Parkinson's disease: progress and challenges
por: Zeng, Xianmin, et al.
Publicado: (2013)

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models
por: Conroy, Faith, et al.
Publicado: (2022)

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease
por: Al-Gharaibeh, Abeer, et al.
Publicado: (2017)

Induced pluripotent stem cells are induced pluripotent stem cell-like cells
por: Song, Liting, et al.
Publicado: (2015)

Induced Pluripotent Stem Cells: Current Progress and Future Perspectives
por: Zhou, Qi
Publicado: (2013)

A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington’s Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities
por: Malankhanova, Tuyana, et al.
Publicado: (2020)

Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research
por: Yagi, Takuya, et al.
Publicado: (2012)

Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia
por: Albert, Katrina, et al.
Publicado: (2021)

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling
por: Bayzigitov, Daniel R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_18f5ur8scqhqookvnfd16s86ga