Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients

Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia a...

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Autores principales: Lehloenya, Rannakoe J., Dlamini, Sipho, Muloiwa, Rudzani, Kakande, Betty, Ngwanya, Mzudumile R., Todd, Gail, Dheda, Keertan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942758/
https://www.ncbi.nlm.nih.gov/pubmed/27419190
http://dx.doi.org/10.1093/ofid/ofw130
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author Lehloenya, Rannakoe J.
Dlamini, Sipho
Muloiwa, Rudzani
Kakande, Betty
Ngwanya, Mzudumile R.
Todd, Gail
Dheda, Keertan
author_facet Lehloenya, Rannakoe J.
Dlamini, Sipho
Muloiwa, Rudzani
Kakande, Betty
Ngwanya, Mzudumile R.
Todd, Gail
Dheda, Keertan
author_sort Lehloenya, Rannakoe J.
collection PubMed
description Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions.
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spelling pubmed-49427582016-07-14 Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients Lehloenya, Rannakoe J. Dlamini, Sipho Muloiwa, Rudzani Kakande, Betty Ngwanya, Mzudumile R. Todd, Gail Dheda, Keertan Open Forum Infect Dis Brief Reports Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions. Oxford University Press 2016-06-20 /pmc/articles/PMC4942758/ /pubmed/27419190 http://dx.doi.org/10.1093/ofid/ofw130 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Lehloenya, Rannakoe J.
Dlamini, Sipho
Muloiwa, Rudzani
Kakande, Betty
Ngwanya, Mzudumile R.
Todd, Gail
Dheda, Keertan
Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients
title Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients
title_full Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients
title_fullStr Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients
title_full_unstemmed Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients
title_short Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients
title_sort therapeutic trial of rifabutin after rifampicin-associated dress syndrome in tuberculosis-human immunodeficiency virus coinfected patients
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942758/
https://www.ncbi.nlm.nih.gov/pubmed/27419190
http://dx.doi.org/10.1093/ofid/ofw130
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