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Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time

There have been notable improvements in survival over the past 2 decades for gastrointestinal (GI) cancer. However, the degree of improvement by age, race, and sex remains unclear. We analyzed data from 9 population-based cancer registries included in the SEER program of the National Cancer Institut...

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Autores principales: Wan, Jue-feng, Yang, Li-feng, Shen, Yun-zhu, Jia, Hui-xun, Zhu, Ji, Li, Gui-chao, Zhang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942771/
https://www.ncbi.nlm.nih.gov/pubmed/27406065
http://dx.doi.org/10.1038/srep29655
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author Wan, Jue-feng
Yang, Li-feng
Shen, Yun-zhu
Jia, Hui-xun
Zhu, Ji
Li, Gui-chao
Zhang, Zhen
author_facet Wan, Jue-feng
Yang, Li-feng
Shen, Yun-zhu
Jia, Hui-xun
Zhu, Ji
Li, Gui-chao
Zhang, Zhen
author_sort Wan, Jue-feng
collection PubMed
description There have been notable improvements in survival over the past 2 decades for gastrointestinal (GI) cancer. However, the degree of improvement by age, race, and sex remains unclear. We analyzed data from 9 population-based cancer registries included in the SEER program of the National Cancer Institute (SEER 9) in 1990 to 2009 (n = 288,337). The degree of survival improvement over time by age, race, and sex was longitudinally measured. From 1990 to 2009, improvements in survival were greater for younger age groups. For patients aged 20 to 49 years and diagnosed from 2005 to 2009, adjusted HRs (95% CIs) were 0.74 (95% CI, 0.66–0.83), 0.49 (95% CI, 0.37–0.64), 0.69 (95% CI, 0.65–0.76), 0.62 (95% CI, 0.54–0.69), and 0.56 (95% CI, 0.42–0.76), for cancer of the stomach, small intestine, colon, rectum and anus, respectively, compared with the same age groups of patients diagnosed during 1990 to 1994. Compared with African Americans, whites experienced greater improvement in small intestinal and anal cancer survival. Female anal cancer and regional anal cancer patients experienced no improvement. Our data suggest that different improvement in survival in age, sex and race exists.
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spelling pubmed-49427712016-07-20 Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time Wan, Jue-feng Yang, Li-feng Shen, Yun-zhu Jia, Hui-xun Zhu, Ji Li, Gui-chao Zhang, Zhen Sci Rep Article There have been notable improvements in survival over the past 2 decades for gastrointestinal (GI) cancer. However, the degree of improvement by age, race, and sex remains unclear. We analyzed data from 9 population-based cancer registries included in the SEER program of the National Cancer Institute (SEER 9) in 1990 to 2009 (n = 288,337). The degree of survival improvement over time by age, race, and sex was longitudinally measured. From 1990 to 2009, improvements in survival were greater for younger age groups. For patients aged 20 to 49 years and diagnosed from 2005 to 2009, adjusted HRs (95% CIs) were 0.74 (95% CI, 0.66–0.83), 0.49 (95% CI, 0.37–0.64), 0.69 (95% CI, 0.65–0.76), 0.62 (95% CI, 0.54–0.69), and 0.56 (95% CI, 0.42–0.76), for cancer of the stomach, small intestine, colon, rectum and anus, respectively, compared with the same age groups of patients diagnosed during 1990 to 1994. Compared with African Americans, whites experienced greater improvement in small intestinal and anal cancer survival. Female anal cancer and regional anal cancer patients experienced no improvement. Our data suggest that different improvement in survival in age, sex and race exists. Nature Publishing Group 2016-07-13 /pmc/articles/PMC4942771/ /pubmed/27406065 http://dx.doi.org/10.1038/srep29655 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wan, Jue-feng
Yang, Li-feng
Shen, Yun-zhu
Jia, Hui-xun
Zhu, Ji
Li, Gui-chao
Zhang, Zhen
Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time
title Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time
title_full Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time
title_fullStr Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time
title_full_unstemmed Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time
title_short Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time
title_sort sex, race, and age disparities in the improvement of survival for gastrointestinal cancer over time
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942771/
https://www.ncbi.nlm.nih.gov/pubmed/27406065
http://dx.doi.org/10.1038/srep29655
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