A novel deleterious c.2656G>T MSH2 germline mutation in a Pakistani family with a phenotypic overlap of hereditary breast and ovarian cancer and Lynch syndrome

BACKGROUND: Hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS) account for a significant proportion of inherited gynecologic malignancies, mainly caused by pathogenic germline mutations in the BRCA1 and BRCA2 genes or in mismatch repair (MMR) genes, such as MLH1 and MSH2. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Rashid, Muhammad U., Naeemi, Humaira, Muhammad, Noor, Loya, Asif, Yusuf, Muhammed A., Lubiński, Jan, Jakubowska, Anna, Hamann, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942885/
https://www.ncbi.nlm.nih.gov/pubmed/27413415
http://dx.doi.org/10.1186/s13053-016-0056-3

Ejemplares similares

Ejemplares similares