G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) enhances viral replication independent of dsRNA-binding activity and type I interferon biology

BACKGROUND: The nonstructural protein 1 (NS1) of influenza A viruses can act as a viral replication enhancer by antagonizing type I interferon (IFN) induction and response in infected cells. We previously reported that A/Puerto Rico/8/1934 (H1N1) (PR8) containing the NS1 gene derived from A/swine/IA...

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Detalles Bibliográficos
Autores principales: Kaewborisuth, Challika, Zanin, Mark, Häcker, Hans, Webby, Richard J., Lekcharoensuk, Porntippa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942902/
https://www.ncbi.nlm.nih.gov/pubmed/27405392
http://dx.doi.org/10.1186/s12985-016-0585-4

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