A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn S...

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Detalles Bibliográficos
Autores principales: Zhang, Liyun, Er, Jun Cheng, Jiang, Hao, Li, Xin, Luo, Zhaofeng, Ramezani, Thomas, Feng, Yi, Tang, Mui Kee, Chang, Young-Tae, Vendrell, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943070/
https://www.ncbi.nlm.nih.gov/pubmed/26940443
http://dx.doi.org/10.1039/c6cc00095a
Descripción
Sumario:Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

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