A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn S...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Liyun, Er, Jun Cheng, Jiang, Hao, Li, Xin, Luo, Zhaofeng, Ramezani, Thomas, Feng, Yi, Tang, Mui Kee, Chang, Young-Tae, Vendrell, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943070/
https://www.ncbi.nlm.nih.gov/pubmed/26940443
http://dx.doi.org/10.1039/c6cc00095a
_version_ 1782442528686997504
author Zhang, Liyun
Er, Jun Cheng
Jiang, Hao
Li, Xin
Luo, Zhaofeng
Ramezani, Thomas
Feng, Yi
Tang, Mui Kee
Chang, Young-Tae
Vendrell, Marc
author_facet Zhang, Liyun
Er, Jun Cheng
Jiang, Hao
Li, Xin
Luo, Zhaofeng
Ramezani, Thomas
Feng, Yi
Tang, Mui Kee
Chang, Young-Tae
Vendrell, Marc
author_sort Zhang, Liyun
collection PubMed
description Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.
format Online
Article
Text
id pubmed-4943070
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-49430702016-07-28 A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase Zhang, Liyun Er, Jun Cheng Jiang, Hao Li, Xin Luo, Zhaofeng Ramezani, Thomas Feng, Yi Tang, Mui Kee Chang, Young-Tae Vendrell, Marc Chem Commun (Camb) Chemistry Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders. Royal Society of Chemistry 2016-07-25 2016-03-04 /pmc/articles/PMC4943070/ /pubmed/26940443 http://dx.doi.org/10.1039/c6cc00095a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Zhang, Liyun
Er, Jun Cheng
Jiang, Hao
Li, Xin
Luo, Zhaofeng
Ramezani, Thomas
Feng, Yi
Tang, Mui Kee
Chang, Young-Tae
Vendrell, Marc
A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase
title A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase
title_full A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase
title_fullStr A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase
title_full_unstemmed A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase
title_short A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase
title_sort highly selective fluorogenic probe for the detection and in vivo imaging of cu/zn superoxide dismutase
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943070/
https://www.ncbi.nlm.nih.gov/pubmed/26940443
http://dx.doi.org/10.1039/c6cc00095a
work_keys_str_mv AT zhangliyun ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT erjuncheng ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT jianghao ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT lixin ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT luozhaofeng ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT ramezanithomas ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT fengyi ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT tangmuikee ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT changyoungtae ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT vendrellmarc ahighlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT zhangliyun highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT erjuncheng highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT jianghao highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT lixin highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT luozhaofeng highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT ramezanithomas highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT fengyi highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT tangmuikee highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT changyoungtae highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase
AT vendrellmarc highlyselectivefluorogenicprobeforthedetectionandinvivoimagingofcuznsuperoxidedismutase

Ejemplares similares