Cargando…

Long‐Term Outcomes Among Elderly Survivors of Out‐of‐Hospital Cardiac Arrest

BACKGROUND: Most studies on out‐of‐hospital cardiac arrest have focused on immediate survival. However, little is known about long‐term outcomes and resource use among survivors. METHODS AND RESULTS: Within the national CARES registry, we identified 16 206 adults 65 years or older with an out‐of‐hos...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, Paul S., McNally, Bryan, Nallamothu, Brahmajee K., Tang, Fengming, Hammill, Bradley G., Spertus, John A., Curtis, Lesley H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943267/
https://www.ncbi.nlm.nih.gov/pubmed/27068632
http://dx.doi.org/10.1161/JAHA.115.002924
_version_ 1782442563242819584
author Chan, Paul S.
McNally, Bryan
Nallamothu, Brahmajee K.
Tang, Fengming
Hammill, Bradley G.
Spertus, John A.
Curtis, Lesley H.
author_facet Chan, Paul S.
McNally, Bryan
Nallamothu, Brahmajee K.
Tang, Fengming
Hammill, Bradley G.
Spertus, John A.
Curtis, Lesley H.
author_sort Chan, Paul S.
collection PubMed
description BACKGROUND: Most studies on out‐of‐hospital cardiac arrest have focused on immediate survival. However, little is known about long‐term outcomes and resource use among survivors. METHODS AND RESULTS: Within the national CARES registry, we identified 16 206 adults 65 years or older with an out‐of‐hospital cardiac arrest between 2005 and 2010. Among 1127 patients who were discharged alive, we evaluated whether 1‐year mortality, cumulative readmission incidence, and follow‐up inpatient costs differed according to patients’ race, sex, initial cardiac arrest rhythm, bystander delivery of cardiopulmonary resuscitation, discharge neurological status, and functional status (hospital discharge disposition). Overall 1‐year mortality after hospital discharge was 31.8%. Among survivors, there were no long‐term mortality differences by sex, race, or initial cardiac arrest rhythm, but worse functional status and severe neurological disability at discharge were associated with higher mortality. Moreover, compared with first responders, cardiopulmonary resuscitation delivered by bystanders was associated with 23% lower mortality (hazard ratio 0.77 [confidence interval 0.58–1.02]). Besides mortality, 638 (56.6%) patients were readmitted within the first year, and the cumulative readmission incidence was 197 per 100 patient‐years. Mean 1‐year inpatient costs were $23 765±41 002. Younger age, black race, severe neurological disability at discharge, and hospital disposition to a skilled nursing or rehabilitation facility were each associated with higher 1‐year inpatient costs (P for all <0.05). CONCLUSION: Among elderly survivors of out‐of‐hospital cardiac arrest, nearly 1 in 3 patients die within the first year. Long‐term mortality and inpatient costs differed substantially by certain demographic factors, whether cardiopulmonary resuscitation was initiated by a bystander, discharge neurological status, and hospital disposition.
format Online
Article
Text
id pubmed-4943267
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-49432672016-07-20 Long‐Term Outcomes Among Elderly Survivors of Out‐of‐Hospital Cardiac Arrest Chan, Paul S. McNally, Bryan Nallamothu, Brahmajee K. Tang, Fengming Hammill, Bradley G. Spertus, John A. Curtis, Lesley H. J Am Heart Assoc Original Research BACKGROUND: Most studies on out‐of‐hospital cardiac arrest have focused on immediate survival. However, little is known about long‐term outcomes and resource use among survivors. METHODS AND RESULTS: Within the national CARES registry, we identified 16 206 adults 65 years or older with an out‐of‐hospital cardiac arrest between 2005 and 2010. Among 1127 patients who were discharged alive, we evaluated whether 1‐year mortality, cumulative readmission incidence, and follow‐up inpatient costs differed according to patients’ race, sex, initial cardiac arrest rhythm, bystander delivery of cardiopulmonary resuscitation, discharge neurological status, and functional status (hospital discharge disposition). Overall 1‐year mortality after hospital discharge was 31.8%. Among survivors, there were no long‐term mortality differences by sex, race, or initial cardiac arrest rhythm, but worse functional status and severe neurological disability at discharge were associated with higher mortality. Moreover, compared with first responders, cardiopulmonary resuscitation delivered by bystanders was associated with 23% lower mortality (hazard ratio 0.77 [confidence interval 0.58–1.02]). Besides mortality, 638 (56.6%) patients were readmitted within the first year, and the cumulative readmission incidence was 197 per 100 patient‐years. Mean 1‐year inpatient costs were $23 765±41 002. Younger age, black race, severe neurological disability at discharge, and hospital disposition to a skilled nursing or rehabilitation facility were each associated with higher 1‐year inpatient costs (P for all <0.05). CONCLUSION: Among elderly survivors of out‐of‐hospital cardiac arrest, nearly 1 in 3 patients die within the first year. Long‐term mortality and inpatient costs differed substantially by certain demographic factors, whether cardiopulmonary resuscitation was initiated by a bystander, discharge neurological status, and hospital disposition. John Wiley and Sons Inc. 2016-03-15 /pmc/articles/PMC4943267/ /pubmed/27068632 http://dx.doi.org/10.1161/JAHA.115.002924 Text en © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Chan, Paul S.
McNally, Bryan
Nallamothu, Brahmajee K.
Tang, Fengming
Hammill, Bradley G.
Spertus, John A.
Curtis, Lesley H.
Long‐Term Outcomes Among Elderly Survivors of Out‐of‐Hospital Cardiac Arrest
title Long‐Term Outcomes Among Elderly Survivors of Out‐of‐Hospital Cardiac Arrest
title_full Long‐Term Outcomes Among Elderly Survivors of Out‐of‐Hospital Cardiac Arrest
title_fullStr Long‐Term Outcomes Among Elderly Survivors of Out‐of‐Hospital Cardiac Arrest
title_full_unstemmed Long‐Term Outcomes Among Elderly Survivors of Out‐of‐Hospital Cardiac Arrest
title_short Long‐Term Outcomes Among Elderly Survivors of Out‐of‐Hospital Cardiac Arrest
title_sort long‐term outcomes among elderly survivors of out‐of‐hospital cardiac arrest
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943267/
https://www.ncbi.nlm.nih.gov/pubmed/27068632
http://dx.doi.org/10.1161/JAHA.115.002924
work_keys_str_mv AT chanpauls longtermoutcomesamongelderlysurvivorsofoutofhospitalcardiacarrest
AT mcnallybryan longtermoutcomesamongelderlysurvivorsofoutofhospitalcardiacarrest
AT nallamothubrahmajeek longtermoutcomesamongelderlysurvivorsofoutofhospitalcardiacarrest
AT tangfengming longtermoutcomesamongelderlysurvivorsofoutofhospitalcardiacarrest
AT hammillbradleyg longtermoutcomesamongelderlysurvivorsofoutofhospitalcardiacarrest
AT spertusjohna longtermoutcomesamongelderlysurvivorsofoutofhospitalcardiacarrest
AT curtislesleyh longtermoutcomesamongelderlysurvivorsofoutofhospitalcardiacarrest