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Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling

BACKGROUND: Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure overload, and both are ameliorated by exogenous tetrahydrob...

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Detalles Bibliográficos
Autores principales:	Hashimoto, Toru, Sivakumaran, Vidhya, Carnicer, Ricardo, Zhu, Guangshuo, Hahn, Virginia S., Bedja, Djahida, Recalde, Alice, Duglan, Drew, Channon, Keith M., Casadei, Barbara, Kass, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943286/ https://www.ncbi.nlm.nih.gov/pubmed/27001967 http://dx.doi.org/10.1161/JAHA.116.003208

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