A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression

We report a patient who developed sebaceous carcinoma on the neck during therapy with immunosuppressive agents (cyclosporine, corticosteroid, methotrexate) for refractory psoriasis vulgaris, which showed rapid enlargement, leading to a fatal outcome. Multiple-organ metastases were detected. Weekly c...

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Autores principales: Shima, Tomoko, Yamamoto, Yuki, Okuhira, Hisako, Mikita, Naoya, Furukawa, Fukumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943301/
https://www.ncbi.nlm.nih.gov/pubmed/27462222
http://dx.doi.org/10.1159/000446342
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author Shima, Tomoko
Yamamoto, Yuki
Okuhira, Hisako
Mikita, Naoya
Furukawa, Fukumi
author_facet Shima, Tomoko
Yamamoto, Yuki
Okuhira, Hisako
Mikita, Naoya
Furukawa, Fukumi
author_sort Shima, Tomoko
collection PubMed
description We report a patient who developed sebaceous carcinoma on the neck during therapy with immunosuppressive agents (cyclosporine, corticosteroid, methotrexate) for refractory psoriasis vulgaris, which showed rapid enlargement, leading to a fatal outcome. Multiple-organ metastases were detected. Weekly carboplatin + paclitaxel therapy resulted in the disappearance of tumor cells, but the patient died of febrile neutropenia. The development of sebaceous carcinoma is rare among psoriasis patients receiving immunosuppressive agents including cyclosporine.
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spelling pubmed-49433012016-07-26 A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression Shima, Tomoko Yamamoto, Yuki Okuhira, Hisako Mikita, Naoya Furukawa, Fukumi Case Rep Dermatol Single Case We report a patient who developed sebaceous carcinoma on the neck during therapy with immunosuppressive agents (cyclosporine, corticosteroid, methotrexate) for refractory psoriasis vulgaris, which showed rapid enlargement, leading to a fatal outcome. Multiple-organ metastases were detected. Weekly carboplatin + paclitaxel therapy resulted in the disappearance of tumor cells, but the patient died of febrile neutropenia. The development of sebaceous carcinoma is rare among psoriasis patients receiving immunosuppressive agents including cyclosporine. S. Karger AG 2016-06-06 /pmc/articles/PMC4943301/ /pubmed/27462222 http://dx.doi.org/10.1159/000446342 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Shima, Tomoko
Yamamoto, Yuki
Okuhira, Hisako
Mikita, Naoya
Furukawa, Fukumi
A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression
title A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression
title_full A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression
title_fullStr A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression
title_full_unstemmed A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression
title_short A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression
title_sort patient with refractory psoriasis who developed sebaceous carcinoma on the neck during cyclosporine therapy and showed rapid progression
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943301/
https://www.ncbi.nlm.nih.gov/pubmed/27462222
http://dx.doi.org/10.1159/000446342
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