Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides

[Image: see text] Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular S(N)Ar, alkylation with silica-supported oligomeric benzyl (Si-O...

Descripción completa

Detalles Bibliográficos
Autores principales: Faisal, Saqib, Maity, Pradip K., Zang, Qin, Samarakoon, Thiwanka B., Sourk, Robert L., Hanson, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943330/
https://www.ncbi.nlm.nih.gov/pubmed/27300570
http://dx.doi.org/10.1021/acscombsci.6b00041
Descripción
Sumario:[Image: see text] Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular S(N)Ar, alkylation with silica-supported oligomeric benzyl (Si-OBP(n)) and triazole (Si-OTP(n)) phosphates, and intermolecular S(N)Ar addition with a number of secondary amines in one-pot to afford a variety of unique benzoxathiazepine 1,1-dioxides sultams in good to excellent yields.

Ejemplares similares