Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides

[Image: see text] Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular S(N)Ar, alkylation with silica-supported oligomeric benzyl (Si-O...

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Autores principales: Faisal, Saqib, Maity, Pradip K., Zang, Qin, Samarakoon, Thiwanka B., Sourk, Robert L., Hanson, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943330/
https://www.ncbi.nlm.nih.gov/pubmed/27300570
http://dx.doi.org/10.1021/acscombsci.6b00041
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author Faisal, Saqib
Maity, Pradip K.
Zang, Qin
Samarakoon, Thiwanka B.
Sourk, Robert L.
Hanson, Paul R.
author_facet Faisal, Saqib
Maity, Pradip K.
Zang, Qin
Samarakoon, Thiwanka B.
Sourk, Robert L.
Hanson, Paul R.
author_sort Faisal, Saqib
collection PubMed
description [Image: see text] Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular S(N)Ar, alkylation with silica-supported oligomeric benzyl (Si-OBP(n)) and triazole (Si-OTP(n)) phosphates, and intermolecular S(N)Ar addition with a number of secondary amines in one-pot to afford a variety of unique benzoxathiazepine 1,1-dioxides sultams in good to excellent yields.
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spelling pubmed-49433302017-06-14 Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides Faisal, Saqib Maity, Pradip K. Zang, Qin Samarakoon, Thiwanka B. Sourk, Robert L. Hanson, Paul R. ACS Comb Sci [Image: see text] Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular S(N)Ar, alkylation with silica-supported oligomeric benzyl (Si-OBP(n)) and triazole (Si-OTP(n)) phosphates, and intermolecular S(N)Ar addition with a number of secondary amines in one-pot to afford a variety of unique benzoxathiazepine 1,1-dioxides sultams in good to excellent yields. American Chemical Society 2016-06-14 2016-07-11 /pmc/articles/PMC4943330/ /pubmed/27300570 http://dx.doi.org/10.1021/acscombsci.6b00041 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Faisal, Saqib
Maity, Pradip K.
Zang, Qin
Samarakoon, Thiwanka B.
Sourk, Robert L.
Hanson, Paul R.
Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides
title Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides
title_full Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides
title_fullStr Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides
title_full_unstemmed Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides
title_short Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides
title_sort application of silica-supported alkylating reagents in a one-pot, sequential protocol to diverse benzoxathiazepine 1,1-dioxides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943330/
https://www.ncbi.nlm.nih.gov/pubmed/27300570
http://dx.doi.org/10.1021/acscombsci.6b00041
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