Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs

Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult animals using delivery routes with the most clinica...

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Detalles Bibliográficos
Autores principales: Miyanohara, Atsushi, Kamizato, Kota, Juhas, Stefan, Juhasova, Jana, Navarro, Michael, Marsala, Silvia, Lukacova, Nada, Hruska-Plochan, Marian, Curtis, Erik, Gabel, Brandon, Ciacci, Joseph, Ahrens, Eric T, Kaspar, Brian K, Cleveland, Don, Marsala, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943453/
https://www.ncbi.nlm.nih.gov/pubmed/27462649
http://dx.doi.org/10.1038/mtm.2016.46

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