Disseminated Talaromyces marneffei and Mycobacterium abscessus in a Patient With Anti-Interferon-γ Autoantibodies

Anti-interferon (IFN)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. We report on disseminated Talaromyces (Penicillium) marneffei and Mycobacterium abscessus infection in a 72-year-old, human im...

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Detalles Bibliográficos
Autores principales: Pruetpongpun, Nattapol, Khawcharoenporn, Thana, Damronglerd, Pansachee, Suthiwartnarueput, Worapop, Apisarnthanarak, Anucha, Rujanavej, Sasinuch, Suwantarat, Nuntra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943537/
https://www.ncbi.nlm.nih.gov/pubmed/27419165
http://dx.doi.org/10.1093/ofid/ofw093
Descripción
Sumario:Anti-interferon (IFN)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. We report on disseminated Talaromyces (Penicillium) marneffei and Mycobacterium abscessus infection in a 72-year-old, human immunodeficiency virus noninfected, Thai man with anti-IFN-γ autoantibody. The patient was successfully treated with antimicrobial therapy and rituximab to control B cell-derived autoantibodies.

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