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Metallo-β-Lactamase (MBL)-Producing Enterobacteriaceae in United States Children

Metallo-β-lactamases (MBLs) are emerging as the most notable resistance determinants in Enterobacteriaceae. In many cases, the genes encoding MBLs are part of complex, mobile genetic elements that carry other resistance determinants. In the United States, there are increasing reports of MBL-producin...

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Autores principales: Logan, Latania K., Bonomo, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943557/
https://www.ncbi.nlm.nih.gov/pubmed/27419164
http://dx.doi.org/10.1093/ofid/ofw090
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author Logan, Latania K.
Bonomo, Robert A.
author_facet Logan, Latania K.
Bonomo, Robert A.
author_sort Logan, Latania K.
collection PubMed
description Metallo-β-lactamases (MBLs) are emerging as the most notable resistance determinants in Enterobacteriaceae. In many cases, the genes encoding MBLs are part of complex, mobile genetic elements that carry other resistance determinants. In the United States, there are increasing reports of MBL-producing Enterobacteriaceae, with New Delhi MBLs (NDMs) accounting for the majority of transmissible MBL infections. Many infections caused by NDM-producing bacteria are associated with international travel and medical tourism. However, little recognition of the introduction of MBL-producing Enterobacteriaceae into the pediatric community has followed. Reports suggest that this occurred as early as 2002. Here, we reflect on the unwelcome emergence of MBL-producing Enterobacteriaceae in US children and the available clinical and molecular data associated with spread. Since 2002, there have been disturbing reports that include the most readily transmissible MBLs, bla(IMP), bla(VIM), and bla(NDM) types. In the majority of children with available data, a history of foreign travel is absent.
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spelling pubmed-49435572016-07-14 Metallo-β-Lactamase (MBL)-Producing Enterobacteriaceae in United States Children Logan, Latania K. Bonomo, Robert A. Open Forum Infect Dis Perspectives Metallo-β-lactamases (MBLs) are emerging as the most notable resistance determinants in Enterobacteriaceae. In many cases, the genes encoding MBLs are part of complex, mobile genetic elements that carry other resistance determinants. In the United States, there are increasing reports of MBL-producing Enterobacteriaceae, with New Delhi MBLs (NDMs) accounting for the majority of transmissible MBL infections. Many infections caused by NDM-producing bacteria are associated with international travel and medical tourism. However, little recognition of the introduction of MBL-producing Enterobacteriaceae into the pediatric community has followed. Reports suggest that this occurred as early as 2002. Here, we reflect on the unwelcome emergence of MBL-producing Enterobacteriaceae in US children and the available clinical and molecular data associated with spread. Since 2002, there have been disturbing reports that include the most readily transmissible MBLs, bla(IMP), bla(VIM), and bla(NDM) types. In the majority of children with available data, a history of foreign travel is absent. Oxford University Press 2016-05-05 /pmc/articles/PMC4943557/ /pubmed/27419164 http://dx.doi.org/10.1093/ofid/ofw090 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Perspectives
Logan, Latania K.
Bonomo, Robert A.
Metallo-β-Lactamase (MBL)-Producing Enterobacteriaceae in United States Children
title Metallo-β-Lactamase (MBL)-Producing Enterobacteriaceae in United States Children
title_full Metallo-β-Lactamase (MBL)-Producing Enterobacteriaceae in United States Children
title_fullStr Metallo-β-Lactamase (MBL)-Producing Enterobacteriaceae in United States Children
title_full_unstemmed Metallo-β-Lactamase (MBL)-Producing Enterobacteriaceae in United States Children
title_short Metallo-β-Lactamase (MBL)-Producing Enterobacteriaceae in United States Children
title_sort metallo-β-lactamase (mbl)-producing enterobacteriaceae in united states children
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943557/
https://www.ncbi.nlm.nih.gov/pubmed/27419164
http://dx.doi.org/10.1093/ofid/ofw090
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