Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology

Myosin heavy chain isoforms are an important component defining fiber type specific properties in skeletal muscle, such as oxidative versus glycolytic metabolism, rate of contraction, and fatigability. While the molecular mechanisms that underlie specification of the different fiber types are becomi...

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Detalles Bibliográficos
Autor principal: Beedle, Aaron M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943764/
https://www.ncbi.nlm.nih.gov/pubmed/27430020
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author Beedle, Aaron M
author_facet Beedle, Aaron M
author_sort Beedle, Aaron M
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description Myosin heavy chain isoforms are an important component defining fiber type specific properties in skeletal muscle, such as oxidative versus glycolytic metabolism, rate of contraction, and fatigability. While the molecular mechanisms that underlie specification of the different fiber types are becoming clearer, how this programming becomes disrupted in muscular dystrophy and the functional consequences of fiber type changes in disease are not fully resolved. Fiber type changes in disease, with specific focus on muscular dystrophies caused by defects in the dystrophin glycoprotein complex, are discussed.
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spelling pubmed-49437642016-07-13 Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology Beedle, Aaron M Musculoskelet Regen Article Myosin heavy chain isoforms are an important component defining fiber type specific properties in skeletal muscle, such as oxidative versus glycolytic metabolism, rate of contraction, and fatigability. While the molecular mechanisms that underlie specification of the different fiber types are becoming clearer, how this programming becomes disrupted in muscular dystrophy and the functional consequences of fiber type changes in disease are not fully resolved. Fiber type changes in disease, with specific focus on muscular dystrophies caused by defects in the dystrophin glycoprotein complex, are discussed. 2016-07-05 2016 /pmc/articles/PMC4943764/ /pubmed/27430020 Text en http://creativecommons.org/licenses/by/4.0/ Licensed under a Creative Commons Attribution 4.0 International License which allows users including authors of articles to copy and redistribute the material in any medium or format, in addition to remix, transform, and build upon the material for any purpose, even commercially, as long as the author and original source are properly cited or credited.
spellingShingle Article
Beedle, Aaron M
Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology
title Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology
title_full Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology
title_fullStr Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology
title_full_unstemmed Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology
title_short Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology
title_sort distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943764/
https://www.ncbi.nlm.nih.gov/pubmed/27430020
work_keys_str_mv AT beedleaaronm distributionofmyosinheavychainisoformsinmusculardystrophyinsightsintodiseasepathology

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