Cargando…

Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy

OBJECTIVE: To assess adherence of the prescribing physicians in a private cancer care center to the American Society of Clinical Oncology guideline for antiemetic prophylaxis, in the first cycle of antineoplastic chemotherapy. METHODS: A total of 139 chemotherapy regimens, of 105 patients, were eval...

Descripción completa

Detalles Bibliográficos
Autores principales: França, Monique Sedlmaier, Usón, Pedro Luiz Serrano, Antunes, Yuri Philippe Pimentel Vieira, Prado, Bernard Lobato, Donnarumma, Carlos del Cistia, Mutão, Taciana Sousa, Rodrigues, Heloisa Veasey, del Giglio, Auro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Ensino e Pesquisa Albert Einstein 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943813/
https://www.ncbi.nlm.nih.gov/pubmed/26154543
http://dx.doi.org/10.1590/S1679-45082015AO3097
_version_ 1782442654770921472
author França, Monique Sedlmaier
Usón, Pedro Luiz Serrano
Antunes, Yuri Philippe Pimentel Vieira
Prado, Bernard Lobato
Donnarumma, Carlos del Cistia
Mutão, Taciana Sousa
Rodrigues, Heloisa Veasey
del Giglio, Auro
author_facet França, Monique Sedlmaier
Usón, Pedro Luiz Serrano
Antunes, Yuri Philippe Pimentel Vieira
Prado, Bernard Lobato
Donnarumma, Carlos del Cistia
Mutão, Taciana Sousa
Rodrigues, Heloisa Veasey
del Giglio, Auro
author_sort França, Monique Sedlmaier
collection PubMed
description OBJECTIVE: To assess adherence of the prescribing physicians in a private cancer care center to the American Society of Clinical Oncology guideline for antiemetic prophylaxis, in the first cycle of antineoplastic chemotherapy. METHODS: A total of 139 chemotherapy regimens, of 105 patients, were evaluated retrospectively from 2011 to 2013. RESULTS: We observed 78% of non-adherence to the guideline rate. The main disagreements with the directive were the prescription of higher doses of dexamethasone and excessive use of 5-HT3 antagonist for low risk emetogenic chemotherapy regimens. On univariate analysis, hematological malignancies (p=0.005), the use of two or more chemotherapy (p=0.05) and high emetogenic risk regimes (p=0.012) were factors statistically associated with greater adherence to guidelines. Treatment based on paclitaxel was the only significant risk factor for non-adherence (p=0.02). By multivariate analysis, the chemotherapy of high emetogenic risk most correlated with adherence to guideline (p=0.05). CONCLUSION: We concluded that the adherence to guidelines is greater if the chemotherapy regime has high emetogenic risk. Educational efforts should focus more intensely on the management of chemotherapy regimens with low and moderate emetogenic potential. Perhaps the development of a computer generated reminder may improve the adherence to guidelines.
format Online
Article
Text
id pubmed-4943813
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Instituto de Ensino e Pesquisa Albert Einstein
record_format MEDLINE/PubMed
spelling pubmed-49438132016-08-10 Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy França, Monique Sedlmaier Usón, Pedro Luiz Serrano Antunes, Yuri Philippe Pimentel Vieira Prado, Bernard Lobato Donnarumma, Carlos del Cistia Mutão, Taciana Sousa Rodrigues, Heloisa Veasey del Giglio, Auro Einstein (Sao Paulo) Original Article OBJECTIVE: To assess adherence of the prescribing physicians in a private cancer care center to the American Society of Clinical Oncology guideline for antiemetic prophylaxis, in the first cycle of antineoplastic chemotherapy. METHODS: A total of 139 chemotherapy regimens, of 105 patients, were evaluated retrospectively from 2011 to 2013. RESULTS: We observed 78% of non-adherence to the guideline rate. The main disagreements with the directive were the prescription of higher doses of dexamethasone and excessive use of 5-HT3 antagonist for low risk emetogenic chemotherapy regimens. On univariate analysis, hematological malignancies (p=0.005), the use of two or more chemotherapy (p=0.05) and high emetogenic risk regimes (p=0.012) were factors statistically associated with greater adherence to guidelines. Treatment based on paclitaxel was the only significant risk factor for non-adherence (p=0.02). By multivariate analysis, the chemotherapy of high emetogenic risk most correlated with adherence to guideline (p=0.05). CONCLUSION: We concluded that the adherence to guidelines is greater if the chemotherapy regime has high emetogenic risk. Educational efforts should focus more intensely on the management of chemotherapy regimens with low and moderate emetogenic potential. Perhaps the development of a computer generated reminder may improve the adherence to guidelines. Instituto de Ensino e Pesquisa Albert Einstein 2015 /pmc/articles/PMC4943813/ /pubmed/26154543 http://dx.doi.org/10.1590/S1679-45082015AO3097 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
França, Monique Sedlmaier
Usón, Pedro Luiz Serrano
Antunes, Yuri Philippe Pimentel Vieira
Prado, Bernard Lobato
Donnarumma, Carlos del Cistia
Mutão, Taciana Sousa
Rodrigues, Heloisa Veasey
del Giglio, Auro
Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy
title Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy
title_full Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy
title_fullStr Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy
title_full_unstemmed Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy
title_short Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy
title_sort assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943813/
https://www.ncbi.nlm.nih.gov/pubmed/26154543
http://dx.doi.org/10.1590/S1679-45082015AO3097
work_keys_str_mv AT francamoniquesedlmaier assessmentofadherencetotheguidelinesforthemanagementofnauseaandvomitinginducedbychemotherapy
AT usonpedroluizserrano assessmentofadherencetotheguidelinesforthemanagementofnauseaandvomitinginducedbychemotherapy
AT antunesyuriphilippepimentelvieira assessmentofadherencetotheguidelinesforthemanagementofnauseaandvomitinginducedbychemotherapy
AT pradobernardlobato assessmentofadherencetotheguidelinesforthemanagementofnauseaandvomitinginducedbychemotherapy
AT donnarummacarlosdelcistia assessmentofadherencetotheguidelinesforthemanagementofnauseaandvomitinginducedbychemotherapy
AT mutaotacianasousa assessmentofadherencetotheguidelinesforthemanagementofnauseaandvomitinginducedbychemotherapy
AT rodriguesheloisaveasey assessmentofadherencetotheguidelinesforthemanagementofnauseaandvomitinginducedbychemotherapy
AT delgiglioauro assessmentofadherencetotheguidelinesforthemanagementofnauseaandvomitinginducedbychemotherapy