Cargando…
Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator
Cancer develops and progresses often by inactivating p53. Here, we unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator. p53 activates NGFR transcription, whereas NGFR inactivates p53 by promoting its MDM2-mediated ubiquitin-dependent proteolysis and by directly bin...
Autores principales: | Zhou, Xiang, Hao, Qian, Liao, Peng, Luo, Shiwen, Zhang, Minhong, Hu, Guohui, Liu, Hongbing, Zhang, Yiwei, Cao, Bo, Baddoo, Melody, Flemington, Erik K, Zeng, Shelya X, Lu, Hua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943851/ https://www.ncbi.nlm.nih.gov/pubmed/27282385 http://dx.doi.org/10.7554/eLife.15099 |
Ejemplares similares
-
Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
por: Chao, Tengfei, et al.
Publicado: (2016) -
Inactivating p53 is essential for nerve growth factor receptor to promote melanoma-initiating cell-stemmed tumorigenesis
por: Jiang, Leiwei, et al.
Publicado: (2020) -
Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation
por: Cao, Bo, et al.
Publicado: (2016) -
SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer
por: Fang, Ziling, et al.
Publicado: (2018) -
TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene
por: Liao, Jun-Ming, et al.
Publicado: (2016)