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The genetic history of Ice Age Europe
Modern humans arrived in Europe ~45,000 years ago, but little is known about their genetic composition before the start of farming ~8,500 years ago. We analyze genome-wide data from 51 Eurasians from ~45,000-7,000 years ago. Over this time, the proportion of Neanderthal DNA decreased from 3–6% to ar...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943878/ https://www.ncbi.nlm.nih.gov/pubmed/27135931 http://dx.doi.org/10.1038/nature17993 |
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| author | Fu, Qiaomei Posth, Cosimo Hajdinjak, Mateja Petr, Martin Mallick, Swapan Fernandes, Daniel Furtwängler, Anja Haak, Wolfgang Meyer, Matthias Mittnik, Alissa Nickel, Birgit Peltzer, Alexander Rohland, Nadin Slon, Viviane Talamo, Sahra Lazaridis, Iosif Lipson, Mark Mathieson, Iain Schiffels, Stephan Skoglund, Pontus Derevianko, Anatoly P. Drozdov, Nikolai Slavinsky, Vyacheslav Tsybankov, Alexander Cremonesi, Renata Grifoni Mallegni, Francesco Gély, Bernard Vacca, Eligio González Morales, Manuel R. Straus, Lawrence G. Neugebauer-Maresch, Christine Teschler-Nicola, Maria Constantin, Silviu Moldovan, Oana Teodora Benazzi, Stefano Peresani, Marco Coppola, Donato Lari, Martina Ricci, Stefano Ronchitelli, Annamaria Valentin, Frédérique Thevenet, Corinne Wehrberger, Kurt Grigorescu, Dan Rougier, Hélène Crevecoeur, Isabelle Flas, Damien Semal, Patrick Mannino, Marcello A. Cupillard, Christophe Bocherens, Hervé Conard, Nicholas J. Harvati, Katerina Moiseyev, Vyacheslav Drucker, Dorothée G. Svoboda, Jiří Richards, Michael P. Caramelli, David Pinhasi, Ron Kelso, Janet Patterson, Nick Krause, Johannes Pääbo, Svante Reich, David |
| author_facet | Fu, Qiaomei Posth, Cosimo Hajdinjak, Mateja Petr, Martin Mallick, Swapan Fernandes, Daniel Furtwängler, Anja Haak, Wolfgang Meyer, Matthias Mittnik, Alissa Nickel, Birgit Peltzer, Alexander Rohland, Nadin Slon, Viviane Talamo, Sahra Lazaridis, Iosif Lipson, Mark Mathieson, Iain Schiffels, Stephan Skoglund, Pontus Derevianko, Anatoly P. Drozdov, Nikolai Slavinsky, Vyacheslav Tsybankov, Alexander Cremonesi, Renata Grifoni Mallegni, Francesco Gély, Bernard Vacca, Eligio González Morales, Manuel R. Straus, Lawrence G. Neugebauer-Maresch, Christine Teschler-Nicola, Maria Constantin, Silviu Moldovan, Oana Teodora Benazzi, Stefano Peresani, Marco Coppola, Donato Lari, Martina Ricci, Stefano Ronchitelli, Annamaria Valentin, Frédérique Thevenet, Corinne Wehrberger, Kurt Grigorescu, Dan Rougier, Hélène Crevecoeur, Isabelle Flas, Damien Semal, Patrick Mannino, Marcello A. Cupillard, Christophe Bocherens, Hervé Conard, Nicholas J. Harvati, Katerina Moiseyev, Vyacheslav Drucker, Dorothée G. Svoboda, Jiří Richards, Michael P. Caramelli, David Pinhasi, Ron Kelso, Janet Patterson, Nick Krause, Johannes Pääbo, Svante Reich, David |
| author_sort | Fu, Qiaomei |
| collection | PubMed |
| description | Modern humans arrived in Europe ~45,000 years ago, but little is known about their genetic composition before the start of farming ~8,500 years ago. We analyze genome-wide data from 51 Eurasians from ~45,000-7,000 years ago. Over this time, the proportion of Neanderthal DNA decreased from 3–6% to around 2%, consistent with natural selection against Neanderthal variants in modern humans. Whereas the earliest modern humans in Europe did not contribute substantially to present-day Europeans, all individuals between ~37,000 and ~14,000 years ago descended from a single founder population which forms part of the ancestry of present-day Europeans. A ~35,000 year old individual from northwest Europe represents an early branch of this founder population which was then displaced across a broad region, before reappearing in southwest Europe during the Ice Age ~19,000 years ago. During the major warming period after ~14,000 years ago, a new genetic component related to present-day Near Easterners appears in Europe. These results document how population turnover and migration have been recurring themes of European pre-history. |
| format | Online Article Text |
| id | pubmed-4943878 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49438782016-11-02 The genetic history of Ice Age Europe Fu, Qiaomei Posth, Cosimo Hajdinjak, Mateja Petr, Martin Mallick, Swapan Fernandes, Daniel Furtwängler, Anja Haak, Wolfgang Meyer, Matthias Mittnik, Alissa Nickel, Birgit Peltzer, Alexander Rohland, Nadin Slon, Viviane Talamo, Sahra Lazaridis, Iosif Lipson, Mark Mathieson, Iain Schiffels, Stephan Skoglund, Pontus Derevianko, Anatoly P. Drozdov, Nikolai Slavinsky, Vyacheslav Tsybankov, Alexander Cremonesi, Renata Grifoni Mallegni, Francesco Gély, Bernard Vacca, Eligio González Morales, Manuel R. Straus, Lawrence G. Neugebauer-Maresch, Christine Teschler-Nicola, Maria Constantin, Silviu Moldovan, Oana Teodora Benazzi, Stefano Peresani, Marco Coppola, Donato Lari, Martina Ricci, Stefano Ronchitelli, Annamaria Valentin, Frédérique Thevenet, Corinne Wehrberger, Kurt Grigorescu, Dan Rougier, Hélène Crevecoeur, Isabelle Flas, Damien Semal, Patrick Mannino, Marcello A. Cupillard, Christophe Bocherens, Hervé Conard, Nicholas J. Harvati, Katerina Moiseyev, Vyacheslav Drucker, Dorothée G. Svoboda, Jiří Richards, Michael P. Caramelli, David Pinhasi, Ron Kelso, Janet Patterson, Nick Krause, Johannes Pääbo, Svante Reich, David Nature Article Modern humans arrived in Europe ~45,000 years ago, but little is known about their genetic composition before the start of farming ~8,500 years ago. We analyze genome-wide data from 51 Eurasians from ~45,000-7,000 years ago. Over this time, the proportion of Neanderthal DNA decreased from 3–6% to around 2%, consistent with natural selection against Neanderthal variants in modern humans. Whereas the earliest modern humans in Europe did not contribute substantially to present-day Europeans, all individuals between ~37,000 and ~14,000 years ago descended from a single founder population which forms part of the ancestry of present-day Europeans. A ~35,000 year old individual from northwest Europe represents an early branch of this founder population which was then displaced across a broad region, before reappearing in southwest Europe during the Ice Age ~19,000 years ago. During the major warming period after ~14,000 years ago, a new genetic component related to present-day Near Easterners appears in Europe. These results document how population turnover and migration have been recurring themes of European pre-history. 2016-05-02 /pmc/articles/PMC4943878/ /pubmed/27135931 http://dx.doi.org/10.1038/nature17993 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms Reprints and permissions information is available at www.nature.com/reprints. |
| spellingShingle | Article Fu, Qiaomei Posth, Cosimo Hajdinjak, Mateja Petr, Martin Mallick, Swapan Fernandes, Daniel Furtwängler, Anja Haak, Wolfgang Meyer, Matthias Mittnik, Alissa Nickel, Birgit Peltzer, Alexander Rohland, Nadin Slon, Viviane Talamo, Sahra Lazaridis, Iosif Lipson, Mark Mathieson, Iain Schiffels, Stephan Skoglund, Pontus Derevianko, Anatoly P. Drozdov, Nikolai Slavinsky, Vyacheslav Tsybankov, Alexander Cremonesi, Renata Grifoni Mallegni, Francesco Gély, Bernard Vacca, Eligio González Morales, Manuel R. Straus, Lawrence G. Neugebauer-Maresch, Christine Teschler-Nicola, Maria Constantin, Silviu Moldovan, Oana Teodora Benazzi, Stefano Peresani, Marco Coppola, Donato Lari, Martina Ricci, Stefano Ronchitelli, Annamaria Valentin, Frédérique Thevenet, Corinne Wehrberger, Kurt Grigorescu, Dan Rougier, Hélène Crevecoeur, Isabelle Flas, Damien Semal, Patrick Mannino, Marcello A. Cupillard, Christophe Bocherens, Hervé Conard, Nicholas J. Harvati, Katerina Moiseyev, Vyacheslav Drucker, Dorothée G. Svoboda, Jiří Richards, Michael P. Caramelli, David Pinhasi, Ron Kelso, Janet Patterson, Nick Krause, Johannes Pääbo, Svante Reich, David The genetic history of Ice Age Europe |
| title | The genetic history of Ice Age Europe |
| title_full | The genetic history of Ice Age Europe |
| title_fullStr | The genetic history of Ice Age Europe |
| title_full_unstemmed | The genetic history of Ice Age Europe |
| title_short | The genetic history of Ice Age Europe |
| title_sort | genetic history of ice age europe |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943878/ https://www.ncbi.nlm.nih.gov/pubmed/27135931 http://dx.doi.org/10.1038/nature17993 |
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