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A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release

Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2a(L174Q) rat)...

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Detalles Bibliográficos
Autores principales:	Tokudome, Kentaro, Okumura, Takahiro, Terada, Ryo, Shimizu, Saki, Kunisawa, Naofumi, Mashimo, Tomoji, Serikawa, Tadao, Sasa, Masashi, Ohno, Yukihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943941/ https://www.ncbi.nlm.nih.gov/pubmed/27471467 http://dx.doi.org/10.3389/fphar.2016.00210

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