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Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5
The hepatocyte nuclear factor 1β gene (HNF1B) is responsible for maturity-onset diabetes of the young type 5 (MODY5), which is characterized by early-onset diabetes mellitus and urogenital malformations. HNF1B is expressed during visceral endoderm formation. We identified a disruption of the great p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944010/ https://www.ncbi.nlm.nih.gov/pubmed/27468355 http://dx.doi.org/10.1038/hgv.2016.22 |
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author | Iwasaki, Naoko Tsurumi, Masashi Asai, Kuniya Shimuzu, Wataru Watanabe, Atsushi Ogata, Makiko Takizawa, Miho Ide, Risa Yamamoto, Toshiyuki Saito, Kayoko |
author_facet | Iwasaki, Naoko Tsurumi, Masashi Asai, Kuniya Shimuzu, Wataru Watanabe, Atsushi Ogata, Makiko Takizawa, Miho Ide, Risa Yamamoto, Toshiyuki Saito, Kayoko |
author_sort | Iwasaki, Naoko |
collection | PubMed |
description | The hepatocyte nuclear factor 1β gene (HNF1B) is responsible for maturity-onset diabetes of the young type 5 (MODY5), which is characterized by early-onset diabetes mellitus and urogenital malformations. HNF1B is expressed during visceral endoderm formation. We identified a disruption of the great pancreatic artery in a patient with MODY5 with no pancreatic body or tail. Our finding supports the significance of HNF1B in the development of the pancreas. |
format | Online Article Text |
id | pubmed-4944010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49440102016-07-27 Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5 Iwasaki, Naoko Tsurumi, Masashi Asai, Kuniya Shimuzu, Wataru Watanabe, Atsushi Ogata, Makiko Takizawa, Miho Ide, Risa Yamamoto, Toshiyuki Saito, Kayoko Hum Genome Var Data Report The hepatocyte nuclear factor 1β gene (HNF1B) is responsible for maturity-onset diabetes of the young type 5 (MODY5), which is characterized by early-onset diabetes mellitus and urogenital malformations. HNF1B is expressed during visceral endoderm formation. We identified a disruption of the great pancreatic artery in a patient with MODY5 with no pancreatic body or tail. Our finding supports the significance of HNF1B in the development of the pancreas. Nature Publishing Group 2016-07-14 /pmc/articles/PMC4944010/ /pubmed/27468355 http://dx.doi.org/10.1038/hgv.2016.22 Text en Copyright © 2016 The Author(s) 2016 http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Data Report Iwasaki, Naoko Tsurumi, Masashi Asai, Kuniya Shimuzu, Wataru Watanabe, Atsushi Ogata, Makiko Takizawa, Miho Ide, Risa Yamamoto, Toshiyuki Saito, Kayoko Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5 |
title | Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5 |
title_full | Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5 |
title_fullStr | Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5 |
title_full_unstemmed | Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5 |
title_short | Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5 |
title_sort | pancreatic developmental defect evaluated by celiac artery angiography in a patient with mody5 |
topic | Data Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944010/ https://www.ncbi.nlm.nih.gov/pubmed/27468355 http://dx.doi.org/10.1038/hgv.2016.22 |
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