L-proline: a highly effective cryoprotectant for mouse oocyte vitrification

Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been appli...

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Autores principales: Zhang, Lu, Xue, Xu, Yan, Jie, Yan, Li-Ying, Jin, Xiao-Hu, Zhu, Xiao-Hui, He, Zhi-Zhu, Liu, Jing, Li, Rong, Qiao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944144/
https://www.ncbi.nlm.nih.gov/pubmed/27412080
http://dx.doi.org/10.1038/srep26326
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author Zhang, Lu
Xue, Xu
Yan, Jie
Yan, Li-Ying
Jin, Xiao-Hu
Zhu, Xiao-Hui
He, Zhi-Zhu
Liu, Jing
Li, Rong
Qiao, Jie
author_facet Zhang, Lu
Xue, Xu
Yan, Jie
Yan, Li-Ying
Jin, Xiao-Hu
Zhu, Xiao-Hui
He, Zhi-Zhu
Liu, Jing
Li, Rong
Qiao, Jie
author_sort Zhang, Lu
collection PubMed
description Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian oocyte vitrification. In this study we evaluated the efficiency and safety of the new cryoprotectant in oocyte vitrification. The results indicated that L-proline improves the survival rate of vitrified oocytes, protects mitochondrial functions and could be applied as a new cryoprotectant in mouse oocyte vitrification.
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spelling pubmed-49441442016-07-20 L-proline: a highly effective cryoprotectant for mouse oocyte vitrification Zhang, Lu Xue, Xu Yan, Jie Yan, Li-Ying Jin, Xiao-Hu Zhu, Xiao-Hui He, Zhi-Zhu Liu, Jing Li, Rong Qiao, Jie Sci Rep Article Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian oocyte vitrification. In this study we evaluated the efficiency and safety of the new cryoprotectant in oocyte vitrification. The results indicated that L-proline improves the survival rate of vitrified oocytes, protects mitochondrial functions and could be applied as a new cryoprotectant in mouse oocyte vitrification. Nature Publishing Group 2016-07-14 /pmc/articles/PMC4944144/ /pubmed/27412080 http://dx.doi.org/10.1038/srep26326 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Lu
Xue, Xu
Yan, Jie
Yan, Li-Ying
Jin, Xiao-Hu
Zhu, Xiao-Hui
He, Zhi-Zhu
Liu, Jing
Li, Rong
Qiao, Jie
L-proline: a highly effective cryoprotectant for mouse oocyte vitrification
title L-proline: a highly effective cryoprotectant for mouse oocyte vitrification
title_full L-proline: a highly effective cryoprotectant for mouse oocyte vitrification
title_fullStr L-proline: a highly effective cryoprotectant for mouse oocyte vitrification
title_full_unstemmed L-proline: a highly effective cryoprotectant for mouse oocyte vitrification
title_short L-proline: a highly effective cryoprotectant for mouse oocyte vitrification
title_sort l-proline: a highly effective cryoprotectant for mouse oocyte vitrification
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944144/
https://www.ncbi.nlm.nih.gov/pubmed/27412080
http://dx.doi.org/10.1038/srep26326
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