Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring

A novel core-shell DNA self-assembly catalyzed by thiol-disulfide exchange reactions was proposed, which could realize GSH-initiated hybridization chain reaction (HCR) for signal amplification and molecules gathering. Significantly, these self-assembled products via electrostatic interaction could a...

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Detalles Bibliográficos
Autores principales: Zhang, Zhen, Jiao, Yuting, Wang, Yuanyuan, Zhang, Shusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944157/
https://www.ncbi.nlm.nih.gov/pubmed/27412605
http://dx.doi.org/10.1038/srep29872
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author Zhang, Zhen
Jiao, Yuting
Wang, Yuanyuan
Zhang, Shusheng
author_facet Zhang, Zhen
Jiao, Yuting
Wang, Yuanyuan
Zhang, Shusheng
author_sort Zhang, Zhen
collection PubMed
description A novel core-shell DNA self-assembly catalyzed by thiol-disulfide exchange reactions was proposed, which could realize GSH-initiated hybridization chain reaction (HCR) for signal amplification and molecules gathering. Significantly, these self-assembled products via electrostatic interaction could accumulate into prominent and clustered fluorescence-bright spots in single cancer cells for reduced glutathione monitoring, which will effectively drive cell monitoring into a new era.
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spelling pubmed-49441572016-07-26 Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring Zhang, Zhen Jiao, Yuting Wang, Yuanyuan Zhang, Shusheng Sci Rep Article A novel core-shell DNA self-assembly catalyzed by thiol-disulfide exchange reactions was proposed, which could realize GSH-initiated hybridization chain reaction (HCR) for signal amplification and molecules gathering. Significantly, these self-assembled products via electrostatic interaction could accumulate into prominent and clustered fluorescence-bright spots in single cancer cells for reduced glutathione monitoring, which will effectively drive cell monitoring into a new era. Nature Publishing Group 2016-07-14 /pmc/articles/PMC4944157/ /pubmed/27412605 http://dx.doi.org/10.1038/srep29872 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Zhen
Jiao, Yuting
Wang, Yuanyuan
Zhang, Shusheng
Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring
title Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring
title_full Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring
title_fullStr Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring
title_full_unstemmed Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring
title_short Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring
title_sort core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944157/
https://www.ncbi.nlm.nih.gov/pubmed/27412605
http://dx.doi.org/10.1038/srep29872
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AT wangyuanyuan coreshellselfassemblytriggeredviaathioldisulfideexchangereactionforreducedglutathionedetectionandsinglecellsmonitoring
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