Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation

Here, we demonstrated that DNA-PKcs is over-expressed in multiple human renal cell carcinoma (RCC) tissues and in primary/established human RCCs. Pharmacological or genetic inhibition of DNA-PKcs suppressed proliferation of RCC cells. DNA-PKcs was in the complex of mTOR and SIN1, mediating mTORC2 ac...

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Detalles Bibliográficos
Autores principales: Zheng, Bing, Mao, Jia-Hui, Li, Xiao-Qing, Qian, Lin, Zhu, Hua, Gu, Dong-hua, Pan, Xiao-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944168/
https://www.ncbi.nlm.nih.gov/pubmed/27412013
http://dx.doi.org/10.1038/srep29415

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