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Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder worldwide. Clinically, AD is characterized by impairments of memory and cognitive functions. Accumulation of amyloid-β (Aβ) and neurofibrillary tangles are the prominent neuropathologies in patients with AD. Strong...

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Detalles Bibliográficos
Autores principales: Velazquez, Ramon, Shaw, Darren M., Caccamo, Antonella, Oddo, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944476/
https://www.ncbi.nlm.nih.gov/pubmed/27412291
http://dx.doi.org/10.1186/s13024-016-0118-z