In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8

BACKGROUND: In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correl...

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Autores principales: Renard, Dimitri, Collombier, Laurent, Castelli, Christel, Pouget, Jean-Pierre, Kotzki, Pierre-Olivier, Boudousq, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944494/
https://www.ncbi.nlm.nih.gov/pubmed/27411408
http://dx.doi.org/10.1186/s12883-016-0630-3
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author Renard, Dimitri
Collombier, Laurent
Castelli, Christel
Pouget, Jean-Pierre
Kotzki, Pierre-Olivier
Boudousq, Vincent
author_facet Renard, Dimitri
Collombier, Laurent
Castelli, Christel
Pouget, Jean-Pierre
Kotzki, Pierre-Olivier
Boudousq, Vincent
author_sort Renard, Dimitri
collection PubMed
description BACKGROUND: In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correlation between CTG-numbers and FDG-PET. METHODS: FDG-PET was performed in 24 patients and compared to 24 controls. Pearson’s correlation was used to analyse correlation. RESULTS: SPM8 revealed Brodmann area 8 as the area with the most severe reduced FDG-uptake. Weak, although not statistically significant, correlation was observed between CTG-numbers and reduced FDG-uptake in Brodmann area 8. CONCLUSION: In DM1, Brodmann area 8 is the area with the most severe reduced FDG-uptake on FDG-PET. Brodmann area 8 reduced FDG-uptake is correlated –although weakly- to CTG-repeat numbers.
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spelling pubmed-49444942016-07-15 In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8 Renard, Dimitri Collombier, Laurent Castelli, Christel Pouget, Jean-Pierre Kotzki, Pierre-Olivier Boudousq, Vincent BMC Neurol Research Article BACKGROUND: In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correlation between CTG-numbers and FDG-PET. METHODS: FDG-PET was performed in 24 patients and compared to 24 controls. Pearson’s correlation was used to analyse correlation. RESULTS: SPM8 revealed Brodmann area 8 as the area with the most severe reduced FDG-uptake. Weak, although not statistically significant, correlation was observed between CTG-numbers and reduced FDG-uptake in Brodmann area 8. CONCLUSION: In DM1, Brodmann area 8 is the area with the most severe reduced FDG-uptake on FDG-PET. Brodmann area 8 reduced FDG-uptake is correlated –although weakly- to CTG-repeat numbers. BioMed Central 2016-07-13 /pmc/articles/PMC4944494/ /pubmed/27411408 http://dx.doi.org/10.1186/s12883-016-0630-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Renard, Dimitri
Collombier, Laurent
Castelli, Christel
Pouget, Jean-Pierre
Kotzki, Pierre-Olivier
Boudousq, Vincent
In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8
title In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8
title_full In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8
title_fullStr In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8
title_full_unstemmed In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8
title_short In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8
title_sort in myotonic dystrophy type 1 reduced fdg-uptake on fdg-pet is most severe in brodmann area 8
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944494/
https://www.ncbi.nlm.nih.gov/pubmed/27411408
http://dx.doi.org/10.1186/s12883-016-0630-3
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