Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals. In patients with hematologic malignancy cell free DNA reflects the underlying tumor mutational profi...

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Autores principales: Hocking, Jay, Mithraprabhu, Sridurga, Kalff, Anna, Spencer, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944540/
https://www.ncbi.nlm.nih.gov/pubmed/27458529
http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0025
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author Hocking, Jay
Mithraprabhu, Sridurga
Kalff, Anna
Spencer, Andrew
author_facet Hocking, Jay
Mithraprabhu, Sridurga
Kalff, Anna
Spencer, Andrew
author_sort Hocking, Jay
collection PubMed
description Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals. In patients with hematologic malignancy cell free DNA reflects the underlying tumor mutational profile, whilst micro-RNAs reflect genetic interference mechanisms within a tumor and potentially the surrounding microenvironment and immune effector cells. These circulating nucleic acids offer a potentially simple, non-invasive, repeatable analysis that can aid in diagnosis, prognosis and therapeutic decisions in cancer treatment.
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spelling pubmed-49445402016-07-25 Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies Hocking, Jay Mithraprabhu, Sridurga Kalff, Anna Spencer, Andrew Cancer Biol Med Review Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals. In patients with hematologic malignancy cell free DNA reflects the underlying tumor mutational profile, whilst micro-RNAs reflect genetic interference mechanisms within a tumor and potentially the surrounding microenvironment and immune effector cells. These circulating nucleic acids offer a potentially simple, non-invasive, repeatable analysis that can aid in diagnosis, prognosis and therapeutic decisions in cancer treatment. Chinese Anti-Cancer Association 2016-06 /pmc/articles/PMC4944540/ /pubmed/27458529 http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0025 Text en Copyright 2016 Cancer Biology & Medicine http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review
Hocking, Jay
Mithraprabhu, Sridurga
Kalff, Anna
Spencer, Andrew
Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies
title Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies
title_full Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies
title_fullStr Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies
title_full_unstemmed Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies
title_short Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies
title_sort liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944540/
https://www.ncbi.nlm.nih.gov/pubmed/27458529
http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0025
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