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High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature

High-grade spindle cell sarcomas are rare undifferentiated pleomorphic cancers that present a treatment challenge to urological practices, especially when they present in the pelvis. We report a 46-year-old male patient who presented to our urology clinic with urinary retention after having a Foley...

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Autores principales: Agafonoff, Slava, Vaidya, Shrikant K., DeFade, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944637/
https://www.ncbi.nlm.nih.gov/pubmed/27453666
http://dx.doi.org/10.4103/0974-7796.184907
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author Agafonoff, Slava
Vaidya, Shrikant K.
DeFade, Brian
author_facet Agafonoff, Slava
Vaidya, Shrikant K.
DeFade, Brian
author_sort Agafonoff, Slava
collection PubMed
description High-grade spindle cell sarcomas are rare undifferentiated pleomorphic cancers that present a treatment challenge to urological practices, especially when they present in the pelvis. We report a 46-year-old male patient who presented to our urology clinic with urinary retention after having a Foley catheter placed at an outlying facility. A voiding trial was attempted, but the patient failed this trial. This failure resulted in cystoscopy with bilateral retrograde pyelograms, which revealed a compressed bladder due to extrinsic compression. This finding had been evaluated with a computed tomography (CT) scan with and without intravenous contrast that showed a 14 cm pelvic mass with bladder displacement and compression. A fine needle aspiration was done at this outlying facility, prior to referral to our office, and it confirmed spindle cell pathology. The mass was surgically excised with the histology revealing a pelvic spindle cell sarcoma with positive surgical margins. Further, metastatic work-up with CT/positron emission tomography revealed bone and lung metastasis. The patient is currently undergoing chemotherapy and radiation. In this case study, we will review staging, management, differential diagnosis, chemotherapy, and radiation.
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spelling pubmed-49446372016-07-22 High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature Agafonoff, Slava Vaidya, Shrikant K. DeFade, Brian Urol Ann Case Report High-grade spindle cell sarcomas are rare undifferentiated pleomorphic cancers that present a treatment challenge to urological practices, especially when they present in the pelvis. We report a 46-year-old male patient who presented to our urology clinic with urinary retention after having a Foley catheter placed at an outlying facility. A voiding trial was attempted, but the patient failed this trial. This failure resulted in cystoscopy with bilateral retrograde pyelograms, which revealed a compressed bladder due to extrinsic compression. This finding had been evaluated with a computed tomography (CT) scan with and without intravenous contrast that showed a 14 cm pelvic mass with bladder displacement and compression. A fine needle aspiration was done at this outlying facility, prior to referral to our office, and it confirmed spindle cell pathology. The mass was surgically excised with the histology revealing a pelvic spindle cell sarcoma with positive surgical margins. Further, metastatic work-up with CT/positron emission tomography revealed bone and lung metastasis. The patient is currently undergoing chemotherapy and radiation. In this case study, we will review staging, management, differential diagnosis, chemotherapy, and radiation. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4944637/ /pubmed/27453666 http://dx.doi.org/10.4103/0974-7796.184907 Text en Copyright: © Urology Annals http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Agafonoff, Slava
Vaidya, Shrikant K.
DeFade, Brian
High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature
title High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature
title_full High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature
title_fullStr High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature
title_full_unstemmed High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature
title_short High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature
title_sort high-grade undifferentiated pleomorphic sarcoma of the pelvis: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944637/
https://www.ncbi.nlm.nih.gov/pubmed/27453666
http://dx.doi.org/10.4103/0974-7796.184907
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