Cargando…

Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome

BACKGROUND: The cardiovascular consequences of obstructive sleep apnoea (OSA) differ by sex. We hypothesized that sex influences the severity of acute coronary syndrome (ACS) in patients with OSA. OSA was defined as an apnoea–hypopnoea index (AHI)>15 events·h(-1). We evaluated the severity of ACS...

Descripción completa

Detalles Bibliográficos
Autores principales: Sánchez-de-la-Torre, Alicia, Abad, Jorge, Durán-Cantolla, Joaquín, Mediano, Olga, Cabriada, Valentín, Masdeu, María José, Terán, Joaquín, Masa, Juan Fernando, de la Peña, Mónica, Aldomá, Albina, Worner, Fernando, Valls, Joan, Barbé, Ferran, Sánchez-de-la-Torre, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944942/
https://www.ncbi.nlm.nih.gov/pubmed/27416494
http://dx.doi.org/10.1371/journal.pone.0159207
_version_ 1782442836479705088
author Sánchez-de-la-Torre, Alicia
Abad, Jorge
Durán-Cantolla, Joaquín
Mediano, Olga
Cabriada, Valentín
Masdeu, María José
Terán, Joaquín
Masa, Juan Fernando
de la Peña, Mónica
Aldomá, Albina
Worner, Fernando
Valls, Joan
Barbé, Ferran
Sánchez-de-la-Torre, Manuel
author_facet Sánchez-de-la-Torre, Alicia
Abad, Jorge
Durán-Cantolla, Joaquín
Mediano, Olga
Cabriada, Valentín
Masdeu, María José
Terán, Joaquín
Masa, Juan Fernando
de la Peña, Mónica
Aldomá, Albina
Worner, Fernando
Valls, Joan
Barbé, Ferran
Sánchez-de-la-Torre, Manuel
author_sort Sánchez-de-la-Torre, Alicia
collection PubMed
description BACKGROUND: The cardiovascular consequences of obstructive sleep apnoea (OSA) differ by sex. We hypothesized that sex influences the severity of acute coronary syndrome (ACS) in patients with OSA. OSA was defined as an apnoea–hypopnoea index (AHI)>15 events·h(-1). We evaluated the severity of ACS according to the ejection fraction, Killip class, number of diseased vessels, number of stents implanted and plasma peak troponin level. METHODS: We included 663 men (mean±SD, AHI 37±18 events·h-(1)) and 133 women (AHI 35±18 events·h-(1)) with OSA. RESULTS: The men were younger than the women (59±11 versus 66±11 years, p<0.0001), exhibited a higher neck circumference (p<0.0001), and were more likely to be smokers and alcohol users than women (p<0.0001, p = 0.0005, respectively). Body mass index and percentage of hypertensive patients or diabetics were similar between sexes. We observed a slight tendency for a higher Killip classification in women, although it was not statistically significant (p = 0.055). For men, we observed that the number of diseased vessels and the number of stents implanted were higher (p = 0.02, p = 0.001, respectively), and a decrease in the ejection fraction (p = 0.002). CONCLUSIONS: This study shows that sex in OSA influences the severity of ACS. Men show a lower ejection fraction and an increased number of diseased vessels and number of stents implanted.
format Online
Article
Text
id pubmed-4944942
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-49449422016-08-08 Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome Sánchez-de-la-Torre, Alicia Abad, Jorge Durán-Cantolla, Joaquín Mediano, Olga Cabriada, Valentín Masdeu, María José Terán, Joaquín Masa, Juan Fernando de la Peña, Mónica Aldomá, Albina Worner, Fernando Valls, Joan Barbé, Ferran Sánchez-de-la-Torre, Manuel PLoS One Research Article BACKGROUND: The cardiovascular consequences of obstructive sleep apnoea (OSA) differ by sex. We hypothesized that sex influences the severity of acute coronary syndrome (ACS) in patients with OSA. OSA was defined as an apnoea–hypopnoea index (AHI)>15 events·h(-1). We evaluated the severity of ACS according to the ejection fraction, Killip class, number of diseased vessels, number of stents implanted and plasma peak troponin level. METHODS: We included 663 men (mean±SD, AHI 37±18 events·h-(1)) and 133 women (AHI 35±18 events·h-(1)) with OSA. RESULTS: The men were younger than the women (59±11 versus 66±11 years, p<0.0001), exhibited a higher neck circumference (p<0.0001), and were more likely to be smokers and alcohol users than women (p<0.0001, p = 0.0005, respectively). Body mass index and percentage of hypertensive patients or diabetics were similar between sexes. We observed a slight tendency for a higher Killip classification in women, although it was not statistically significant (p = 0.055). For men, we observed that the number of diseased vessels and the number of stents implanted were higher (p = 0.02, p = 0.001, respectively), and a decrease in the ejection fraction (p = 0.002). CONCLUSIONS: This study shows that sex in OSA influences the severity of ACS. Men show a lower ejection fraction and an increased number of diseased vessels and number of stents implanted. Public Library of Science 2016-07-14 /pmc/articles/PMC4944942/ /pubmed/27416494 http://dx.doi.org/10.1371/journal.pone.0159207 Text en © 2016 Sánchez-de-la-Torre et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sánchez-de-la-Torre, Alicia
Abad, Jorge
Durán-Cantolla, Joaquín
Mediano, Olga
Cabriada, Valentín
Masdeu, María José
Terán, Joaquín
Masa, Juan Fernando
de la Peña, Mónica
Aldomá, Albina
Worner, Fernando
Valls, Joan
Barbé, Ferran
Sánchez-de-la-Torre, Manuel
Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome
title Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome
title_full Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome
title_fullStr Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome
title_full_unstemmed Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome
title_short Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome
title_sort effect of patient sex on the severity of coronary artery disease in patients with newly diagnosis of obstructive sleep apnoea admitted by an acute coronary syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944942/
https://www.ncbi.nlm.nih.gov/pubmed/27416494
http://dx.doi.org/10.1371/journal.pone.0159207
work_keys_str_mv AT sanchezdelatorrealicia effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT abadjorge effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT durancantollajoaquin effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT medianoolga effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT cabriadavalentin effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT masdeumariajose effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT teranjoaquin effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT masajuanfernando effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT delapenamonica effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT aldomaalbina effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT wornerfernando effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT vallsjoan effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT barbeferran effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT sanchezdelatorremanuel effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome
AT effectofpatientsexontheseverityofcoronaryarterydiseaseinpatientswithnewlydiagnosisofobstructivesleepapnoeaadmittedbyanacutecoronarysyndrome