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CD4(+) T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART

HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. We hypothesized that CD4(+) T cells expressing immune c...

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Detalles Bibliográficos
Autores principales: Fromentin, Rémi, Bakeman, Wendy, Lawani, Mariam B., Khoury, Gabriela, Hartogensis, Wendy, DaFonseca, Sandrina, Killian, Marisela, Epling, Lorrie, Hoh, Rebecca, Sinclair, Elizabeth, Hecht, Frederick M., Bacchetti, Peter, Deeks, Steven G., Lewin, Sharon R., Sékaly, Rafick-Pierre, Chomont, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944956/
https://www.ncbi.nlm.nih.gov/pubmed/27415008
http://dx.doi.org/10.1371/journal.ppat.1005761