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Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways

Transforming growth factor β (TGFβ)-induced epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) plays a key role in the pathogenesis of anterior subcapsular cataract (ASC) and capsule opacification. In mouse lens, Sprouty2 (Spry2) has a negative regulatory role on TGFβ signaling....

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Detalles Bibliográficos
Autores principales:	Tan, Xuhua, Zhu, Yi, Chen, Chuan, Chen, Xiaoyun, Qin, Yingyan, Qu, Bo, Luo, Lixia, Lin, Haotian, Wu, Mingxing, Chen, Weirong, Liu, Yizhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944964/ https://www.ncbi.nlm.nih.gov/pubmed/27415760 http://dx.doi.org/10.1371/journal.pone.0159275

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